Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

Progress toward understanding the pathogenesis of cystic fibrosis (CF) and developing effective therapies has been hampered by lack of a relevant animal model. CF mice fail to develop the lung and pancreatic disease that cause most of the morbidity and mortality in patients with CF. Pigs may be bett...

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Veröffentlicht in:	The Journal of clinical investigation 2008-04, Vol.118 (4), p.1571-1577
Hauptverfasser:	Rogers, Christopher S, Hao, Yanhong, Rokhlina, Tatiana, Samuel, Melissa, Stoltz, David A, Li, Yuhong, Petroff, Elena, Vermeer, Daniel W, Kabel, Amanda C, Yan, Ziying, Spate, Lee, Wax, David, Murphy, Clifton N, Rieke, August, Whitworth, Kristin, Linville, Michael L, Korte, Scott W, Engelhardt, John F, Welsh, Michael J, Prather, Randall S
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome abnormalities Complications and side effects Gene expression Mutation (Biology) Risk factors Technical Advance
Online-Zugang:	Volltext
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