Destruction of the Main Olfactory Epithelium Reduces Female Sexual Behavior and Olfactory Investigation in Female Mice
We studied the contribution of the main olfactory system to mate recognition and sexual behavior in female mice. Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to destroy the main olfactory epithelium (MOE) or saline (SAL) to serve as control. ZnSO4-treated f...
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| Veröffentlicht in: | Chemical senses 2006-05, Vol.31 (4), p.315-323 |
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| creator | Keller, Matthieu Douhard, Quentin Baum, Michael J. Bakker, Julie |
| description | We studied the contribution of the main olfactory system to mate recognition and sexual behavior in female mice. Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to destroy the main olfactory epithelium (MOE) or saline (SAL) to serve as control. ZnSO4-treated female mice were no longer able to reliably distinguish between volatile as well as nonvolatile odors from an intact versus a castrated male. Furthermore, sexual behavior in mating tests with a sexually experienced male was significantly reduced in ZnSO4-treated female mice. Vomeronasal function did not seem to be affected by ZnSO4 treatment: nasal application of male urine induced similar levels of Fos protein in the mitral and granule cells of the accessory olfactory bulb (AOB) of ZnSO4 as well as SAL-treated female mice. Likewise, soybean agglutinin staining, which stains the axons of vomeronasal neurons projecting to the glomerular layer of the AOB was similar in ZnSO4-treated female mice compared to SAL-treated female mice. By contrast, a significant reduction of Fos in the main olfactory bulb was observed in ZnSO4-treated females in comparison to SAL-treated animals, confirming a substantial destruction of the MOE. These results show that the MOE is primarily involved in the detection and processing of odors that are used to localize and identify the sex and endocrine status of conspecifics. By contrast, both the main and accessory olfactory systems contribute to female sexual receptivity in female mice. |
| doi_str_mv | 10.1093/chemse/bjj035 |
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Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to destroy the main olfactory epithelium (MOE) or saline (SAL) to serve as control. ZnSO4-treated female mice were no longer able to reliably distinguish between volatile as well as nonvolatile odors from an intact versus a castrated male. Furthermore, sexual behavior in mating tests with a sexually experienced male was significantly reduced in ZnSO4-treated female mice. Vomeronasal function did not seem to be affected by ZnSO4 treatment: nasal application of male urine induced similar levels of Fos protein in the mitral and granule cells of the accessory olfactory bulb (AOB) of ZnSO4 as well as SAL-treated female mice. Likewise, soybean agglutinin staining, which stains the axons of vomeronasal neurons projecting to the glomerular layer of the AOB was similar in ZnSO4-treated female mice compared to SAL-treated female mice. By contrast, a significant reduction of Fos in the main olfactory bulb was observed in ZnSO4-treated females in comparison to SAL-treated animals, confirming a substantial destruction of the MOE. These results show that the MOE is primarily involved in the detection and processing of odors that are used to localize and identify the sex and endocrine status of conspecifics. By contrast, both the main and accessory olfactory systems contribute to female sexual receptivity in female mice.</description><identifier>ISSN: 0379-864X</identifier><identifier>ISSN: 1464-3553</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bjj035</identifier><identifier>PMID: 16484502</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animal ethology ; Animals ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Human health sciences ; main olfactory system ; Male ; Mammalia ; Mice ; Mice, Inbred C57BL ; Neurologie ; Neurology ; Neurosciences & behavior ; Neurosciences & comportement ; Odorants ; Olfaction. Taste ; Olfactory Bulb - pathology ; Olfactory Bulb - physiology ; Olfactory Mucosa - cytology ; Olfactory Mucosa - drug effects ; Olfactory Mucosa - physiology ; Perception ; Posture ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Sciences de la santé humaine ; Sciences sociales & comportementales, psychologie ; Sensitivity and Specificity ; sex recognition ; sexual behavior ; Sexual Behavior, Animal - drug effects ; Sexual Behavior, Animal - physiology ; Smell - drug effects ; Smell - physiology ; Social & behavioral sciences, psychology ; Vertebrata ; zinc sulfate ; Zinc Sulfate - pharmacology</subject><ispartof>Chemical senses, 2006-05, Vol.31 (4), p.315-323</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-907bb8b469f94d4c0245436f7565dad3deb1fe31d69f320cb9562986cb5502fe3</citedby><cites>FETCH-LOGICAL-c620t-907bb8b469f94d4c0245436f7565dad3deb1fe31d69f320cb9562986cb5502fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17747327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16484502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keller, Matthieu</creatorcontrib><creatorcontrib>Douhard, Quentin</creatorcontrib><creatorcontrib>Baum, Michael J.</creatorcontrib><creatorcontrib>Bakker, Julie</creatorcontrib><title>Destruction of the Main Olfactory Epithelium Reduces Female Sexual Behavior and Olfactory Investigation in Female Mice</title><title>Chemical senses</title><addtitle>Chem. Senses</addtitle><description>We studied the contribution of the main olfactory system to mate recognition and sexual behavior in female mice. Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to destroy the main olfactory epithelium (MOE) or saline (SAL) to serve as control. ZnSO4-treated female mice were no longer able to reliably distinguish between volatile as well as nonvolatile odors from an intact versus a castrated male. Furthermore, sexual behavior in mating tests with a sexually experienced male was significantly reduced in ZnSO4-treated female mice. Vomeronasal function did not seem to be affected by ZnSO4 treatment: nasal application of male urine induced similar levels of Fos protein in the mitral and granule cells of the accessory olfactory bulb (AOB) of ZnSO4 as well as SAL-treated female mice. Likewise, soybean agglutinin staining, which stains the axons of vomeronasal neurons projecting to the glomerular layer of the AOB was similar in ZnSO4-treated female mice compared to SAL-treated female mice. By contrast, a significant reduction of Fos in the main olfactory bulb was observed in ZnSO4-treated females in comparison to SAL-treated animals, confirming a substantial destruction of the MOE. These results show that the MOE is primarily involved in the detection and processing of odors that are used to localize and identify the sex and endocrine status of conspecifics. By contrast, both the main and accessory olfactory systems contribute to female sexual receptivity in female mice.</description><subject>Animal ethology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human health sciences</subject><subject>main olfactory system</subject><subject>Male</subject><subject>Mammalia</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurologie</subject><subject>Neurology</subject><subject>Neurosciences & behavior</subject><subject>Neurosciences & comportement</subject><subject>Odorants</subject><subject>Olfaction. Taste</subject><subject>Olfactory Bulb - pathology</subject><subject>Olfactory Bulb - physiology</subject><subject>Olfactory Mucosa - cytology</subject><subject>Olfactory Mucosa - drug effects</subject><subject>Olfactory Mucosa - physiology</subject><subject>Perception</subject><subject>Posture</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Sciences de la santé humaine</subject><subject>Sciences sociales & comportementales, psychologie</subject><subject>Sensitivity and Specificity</subject><subject>sex recognition</subject><subject>sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Smell - drug effects</subject><subject>Smell - physiology</subject><subject>Social & behavioral sciences, psychology</subject><subject>Vertebrata</subject><subject>zinc sulfate</subject><subject>Zinc Sulfate - pharmacology</subject><issn>0379-864X</issn><issn>1464-3553</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktvEzEUhS0EoiWwZItGSLAb6rfHG6RSGlopVREPqcrG8njuJA7zCPZM1P573CRqChvkhS3f75yre3QRek3wB4I1O3FLaCOclKsVZuIJOiZc8pwJwZ6iY8yUzgvJb47QixhXGBPOaPEcHRHJCy4wPUabzxCHMLrB913W19mwhOzK-i67bmrrhj7cZedrn34bP7bZN6hGBzGbQmsbyL7D7Wib7BMs7cb3IbNd9Uh32W2St1_YrXey3KuuvIOX6Fltmwiv9vcE_Zye_zi7yGfXXy7PTme5kxQPucaqLIuSS11rXnGHKRecyVoJKSpbsQpKUgMjVQIYxa7UQlJdSFeKNF2qTNDHne96LFuoHHRDsI1ZB9_acGd6683flc4vzaLfGEolI-lMEN0ZNB4WYPpQerOhW-H2PTYLY50p4V5RGE0E5Un0ft819L_HFIJpfXTQNLaDfoxGKs0E0-K_IFGEK751fPsPuOrH0KXoDNGapjiYTFC-g1zoYwxQP8xJsLlfFrNbFrNblsS_eRzOgd5vRwLe7QEbnW3qYDvn44FTiitG1aGxjwPcPtRt-JVGZUqYi5u5UV_neDon0szYHxdR2fw</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Keller, Matthieu</creator><creator>Douhard, Quentin</creator><creator>Baum, Michael J.</creator><creator>Bakker, Julie</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><general>Oxford Univ Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope></search><sort><creationdate>20060501</creationdate><title>Destruction of the Main Olfactory Epithelium Reduces Female Sexual Behavior and Olfactory Investigation in Female Mice</title><author>Keller, Matthieu ; Douhard, Quentin ; Baum, Michael J. ; Bakker, Julie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-907bb8b469f94d4c0245436f7565dad3deb1fe31d69f320cb9562986cb5502fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal ethology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human health sciences</topic><topic>main olfactory system</topic><topic>Male</topic><topic>Mammalia</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neurologie</topic><topic>Neurology</topic><topic>Neurosciences & behavior</topic><topic>Neurosciences & comportement</topic><topic>Odorants</topic><topic>Olfaction. Taste</topic><topic>Olfactory Bulb - pathology</topic><topic>Olfactory Bulb - physiology</topic><topic>Olfactory Mucosa - cytology</topic><topic>Olfactory Mucosa - drug effects</topic><topic>Olfactory Mucosa - physiology</topic><topic>Perception</topic><topic>Posture</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Sciences de la santé humaine</topic><topic>Sciences sociales & comportementales, psychologie</topic><topic>Sensitivity and Specificity</topic><topic>sex recognition</topic><topic>sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Smell - drug effects</topic><topic>Smell - physiology</topic><topic>Social & behavioral sciences, psychology</topic><topic>Vertebrata</topic><topic>zinc sulfate</topic><topic>Zinc Sulfate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keller, Matthieu</creatorcontrib><creatorcontrib>Douhard, Quentin</creatorcontrib><creatorcontrib>Baum, Michael J.</creatorcontrib><creatorcontrib>Bakker, Julie</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keller, Matthieu</au><au>Douhard, Quentin</au><au>Baum, Michael J.</au><au>Bakker, Julie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Destruction of the Main Olfactory Epithelium Reduces Female Sexual Behavior and Olfactory Investigation in Female Mice</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem. Senses</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>31</volume><issue>4</issue><spage>315</spage><epage>323</epage><pages>315-323</pages><issn>0379-864X</issn><issn>1464-3553</issn><eissn>1464-3553</eissn><coden>CHSED8</coden><abstract>We studied the contribution of the main olfactory system to mate recognition and sexual behavior in female mice. Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to destroy the main olfactory epithelium (MOE) or saline (SAL) to serve as control. ZnSO4-treated female mice were no longer able to reliably distinguish between volatile as well as nonvolatile odors from an intact versus a castrated male. Furthermore, sexual behavior in mating tests with a sexually experienced male was significantly reduced in ZnSO4-treated female mice. Vomeronasal function did not seem to be affected by ZnSO4 treatment: nasal application of male urine induced similar levels of Fos protein in the mitral and granule cells of the accessory olfactory bulb (AOB) of ZnSO4 as well as SAL-treated female mice. Likewise, soybean agglutinin staining, which stains the axons of vomeronasal neurons projecting to the glomerular layer of the AOB was similar in ZnSO4-treated female mice compared to SAL-treated female mice. By contrast, a significant reduction of Fos in the main olfactory bulb was observed in ZnSO4-treated females in comparison to SAL-treated animals, confirming a substantial destruction of the MOE. These results show that the MOE is primarily involved in the detection and processing of odors that are used to localize and identify the sex and endocrine status of conspecifics. By contrast, both the main and accessory olfactory systems contribute to female sexual receptivity in female mice.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16484502</pmid><doi>10.1093/chemse/bjj035</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal ethology Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Human health sciences main olfactory system Male Mammalia Mice Mice, Inbred C57BL Neurologie Neurology Neurosciences & behavior Neurosciences & comportement Odorants Olfaction. Taste Olfactory Bulb - pathology Olfactory Bulb - physiology Olfactory Mucosa - cytology Olfactory Mucosa - drug effects Olfactory Mucosa - physiology Perception Posture Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sciences de la santé humaine Sciences sociales & comportementales, psychologie Sensitivity and Specificity sex recognition sexual behavior Sexual Behavior, Animal - drug effects Sexual Behavior, Animal - physiology Smell - drug effects Smell - physiology Social & behavioral sciences, psychology Vertebrata zinc sulfate Zinc Sulfate - pharmacology |
| title | Destruction of the Main Olfactory Epithelium Reduces Female Sexual Behavior and Olfactory Investigation in Female Mice |
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