4-Methyl Sterols Regulate Fission Yeast SREBP-Scap under Low Oxygen and Cell Stress

In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply. Under low oxygen conditions, sterol synthesis is inhibited, and Sre1 cleavage is activated. However, the sterol signal for Sre1 activation...

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Veröffentlicht in:	The Journal of biological chemistry 2007-08, Vol.282 (33), p.24388-24396
Hauptverfasser:	Hughes, Adam L., Lee, Chih-Yung S., Bien, Clara M., Espenshade, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cryptococcus neoformans Gene Expression Regulation, Fungal Lanosterol Mutation Oxidative Stress Oxygen Schizosaccharomyces - metabolism Schizosaccharomyces pombe Sterol Regulatory Element Binding Proteins - genetics Sterol Regulatory Element Binding Proteins - metabolism Sterols - biosynthesis Sterols - pharmacology
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