Synthesis and biological activity of 5-aza-ellipticine derivatives
Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-04, Vol.17 (8), p.2380-2384 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Moody, Deborah L. Dyba, Marcin Kosakowska-Cholody, Teresa Tarasova, Nadya I. Michejda, Christopher J. |
| description | Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents. |
| doi_str_mv | 10.1016/j.bmcl.2006.09.093 |
| format | Article |
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The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2006.09.093</identifier><identifier>PMID: 17376678</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>5-Aza-ellipticine ; Anti-tumor agents ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Aza Compounds - chemical synthesis ; Aza Compounds - pharmacology ; Biological and medical sciences ; Cell Line ; Cell Survival - drug effects ; Ellipticine ; Ellipticines - chemical synthesis ; Ellipticines - pharmacology ; General aspects ; Humans ; Inhibitory Concentration 50 ; Medical sciences ; Pharmacology. 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The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents.</description><subject>5-Aza-ellipticine</subject><subject>Anti-tumor agents</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Aza Compounds - chemical synthesis</subject><subject>Aza Compounds - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Ellipticine</subject><subject>Ellipticines - chemical synthesis</subject><subject>Ellipticines - pharmacology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Structure-Activity Relationship</subject><subject>Topoisomerase II</subject><subject>Topoisomerase II Inhibitors</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi1ERUPhD3BAe6G3Tf21XltCSFBBi1SJA1TqzXJmZ9uJNutgbyKlvx6HRBQuSCP5MM-8M34YeyP4XHBhLpbzxQqGueTczLkrpZ6xmdBG10rz5jmbcWd4bZ2-O2Uvc15yLjTX-gU7Fa1qjWntjH36vhunB8yUqzB21YLiEO8JwlAFmGhL066KfdXU4THUOAy0nghoxKrDRNtQCMyv2Ekfhoyvj-8Zu_3y-cfldX3z7err5cebGhrLp1rZRlrsDSgjXQMSdFDBqsB7C1IgOLUw0HQKeK-wVQIUaCFcLzlga22rztiHQ-56s1hhBzhOKQx-nWgV0s7HQP7fzkgP_j5uvZRGyt8B58eAFH9uME9-RRnKr8KIcZO9cI1wRpgCygMIKeacsP-zRHC_V--Xfq_e79V77kqpMvT27_OeRo6uC_DuCIRcBPcpjED5ibOmsUq7wr0_cFhkbgmTz0A4AnaUECbfRfrfHb8AqGKjaA</recordid><startdate>20070415</startdate><enddate>20070415</enddate><creator>Moody, Deborah L.</creator><creator>Dyba, Marcin</creator><creator>Kosakowska-Cholody, Teresa</creator><creator>Tarasova, Nadya I.</creator><creator>Michejda, Christopher J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20070415</creationdate><title>Synthesis and biological activity of 5-aza-ellipticine derivatives</title><author>Moody, Deborah L. ; Dyba, Marcin ; Kosakowska-Cholody, Teresa ; Tarasova, Nadya I. ; Michejda, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-38528ef6c36295c2c4a3a83a0f8c21ec93b6c5d3c0f3e731c3c4119f20ce78873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>5-Aza-ellipticine</topic><topic>Anti-tumor agents</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Aza Compounds - chemical synthesis</topic><topic>Aza Compounds - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Ellipticine</topic><topic>Ellipticines - chemical synthesis</topic><topic>Ellipticines - pharmacology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Structure-Activity Relationship</topic><topic>Topoisomerase II</topic><topic>Topoisomerase II Inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moody, Deborah L.</creatorcontrib><creatorcontrib>Dyba, Marcin</creatorcontrib><creatorcontrib>Kosakowska-Cholody, Teresa</creatorcontrib><creatorcontrib>Tarasova, Nadya I.</creatorcontrib><creatorcontrib>Michejda, Christopher J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moody, Deborah L.</au><au>Dyba, Marcin</au><au>Kosakowska-Cholody, Teresa</au><au>Tarasova, Nadya I.</au><au>Michejda, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and biological activity of 5-aza-ellipticine derivatives</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2007-04-15</date><risdate>2007</risdate><volume>17</volume><issue>8</issue><spage>2380</spage><epage>2384</epage><pages>2380-2384</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. 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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2380-2384 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5-Aza-ellipticine Anti-tumor agents Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Aza Compounds - chemical synthesis Aza Compounds - pharmacology Biological and medical sciences Cell Line Cell Survival - drug effects Ellipticine Ellipticines - chemical synthesis Ellipticines - pharmacology General aspects Humans Inhibitory Concentration 50 Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Topoisomerase II Topoisomerase II Inhibitors |
| title | Synthesis and biological activity of 5-aza-ellipticine derivatives |
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