Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

Bardet-Biedl syndrome (BBS) is a heterogeneous genetic disorder characterized by many features, including obesity and cardiovascular disease. We previously developed knockout mouse models of 3 BBS genes: BBS2, BBS4, and BBS6. To dissect the mechanisms involved in the metabolic disorders associated w...

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Veröffentlicht in:	The Journal of clinical investigation 2008-04, Vol.118 (4), p.1458-1467
Hauptverfasser:	Rahmouni, Kamal, Fath, Melissa A, Seo, Seongjin, Thedens, Daniel R, Berry, Christopher J, Weiss, Robert, Nishimura, Darryl Y, Sheffield, Val C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bardet-Biedl syndrome Bardet-Biedl Syndrome - genetics Bardet-Biedl Syndrome - metabolism Bardet-Biedl Syndrome - pathology Biomedical research Blood-Brain Barrier - drug effects Body fat Body Weight - drug effects Care and treatment Complications and side effects Disease Models, Animal Electrocardiography Energy Gene Expression Regulation - drug effects Genes Group II Chaperonins Homeostasis Hypertension Hypertension - genetics Hypertension - metabolism Hypothalamus Leptin - pharmacology Magnetic Resonance Imaging Metabolism Mice Mice, Knockout Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Nervous system Neuropeptides Obesity Obesity - genetics Obesity - metabolism Organ Size Proteins - genetics Proteins - metabolism Risk factors
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