Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study
In the present study, water extract of dried fruit of Zyzyphus Jujube was tested for its possible anticancer effect and induction of apoptosis on human tumor cell lines, HEp-2, HeLa and Jurkat cell lines. The inhibitory effect of water extract of this fruit on cell proliferation was assessed by MTT...
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| Veröffentlicht in: | Cytotechnology (Dordrecht) 2008-02, Vol.56 (2), p.105-111 |
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| creator | Vahedi, Fatemeh Fathi Najafi, Mohsen Bozari, Kazem |
| description | In the present study, water extract of dried fruit of Zyzyphus Jujube was tested for its possible anticancer effect and induction of apoptosis on human tumor cell lines, HEp-2, HeLa and Jurkat cell lines. The inhibitory effect of water extract of this fruit on cell proliferation was assessed by MTT colorimetric assay. The induction of apoptosis of this extract was analyzed by DNA fragmentation analysis. Zyzyphus Jujube extract showed inhibitory effects on mentioned cell lines. Jurkat leukemic line was found the most sensitive cells with IC50 of 0.1 μg mL
−1
. Our study also showed a typical DNA laddering in this cell line. The present study showed cytotoxic activity of Zyzyphus Jujube on tumor cells. Although Zyzyphus Jujube has useful compounds for medical applications. |
| doi_str_mv | 10.1007/s10616-008-9131-6 |
| format | Article |
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−1
. Our study also showed a typical DNA laddering in this cell line. The present study showed cytotoxic activity of Zyzyphus Jujube on tumor cells. Although Zyzyphus Jujube has useful compounds for medical applications.</description><identifier>ISSN: 0920-9069</identifier><identifier>EISSN: 1573-0778</identifier><identifier>DOI: 10.1007/s10616-008-9131-6</identifier><identifier>PMID: 19002848</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Apoptosis ; Biochemistry ; Biological and medical sciences ; Biomedicine ; Biotechnology ; Cancer ; Cell growth ; Cell proliferation ; Chemistry ; Chemistry and Materials Science ; Colorimetry ; Cytotoxicity ; Disease prevention ; DNA fragmentation ; Fruits ; Fundamental and applied biological sciences. Psychology ; Hemodialysis ; Leukemia ; Morphology ; Original Research Paper ; Phenols ; Proteins ; Tumor cell lines ; Tumor cells ; Tumors</subject><ispartof>Cytotechnology (Dordrecht), 2008-02, Vol.56 (2), p.105-111</ispartof><rights>Springer Science+Business Media B.V. 2008</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media B.V. 2008.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-3b8002c89ea6ec327b0b14e6894fb79e830e164c4cbe09e2c11608ac28dd43953</citedby><cites>FETCH-LOGICAL-c530t-3b8002c89ea6ec327b0b14e6894fb79e830e164c4cbe09e2c11608ac28dd43953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259261/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918251249?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,21375,27911,27912,33731,33732,41475,42544,43792,51306,53778,53780,64370,64372,64374,72224</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20178793$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19002848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vahedi, Fatemeh</creatorcontrib><creatorcontrib>Fathi Najafi, Mohsen</creatorcontrib><creatorcontrib>Bozari, Kazem</creatorcontrib><title>Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study</title><title>Cytotechnology (Dordrecht)</title><addtitle>Cytotechnology</addtitle><addtitle>Cytotechnology</addtitle><description>In the present study, water extract of dried fruit of Zyzyphus Jujube was tested for its possible anticancer effect and induction of apoptosis on human tumor cell lines, HEp-2, HeLa and Jurkat cell lines. The inhibitory effect of water extract of this fruit on cell proliferation was assessed by MTT colorimetric assay. The induction of apoptosis of this extract was analyzed by DNA fragmentation analysis. Zyzyphus Jujube extract showed inhibitory effects on mentioned cell lines. Jurkat leukemic line was found the most sensitive cells with IC50 of 0.1 μg mL
−1
. Our study also showed a typical DNA laddering in this cell line. The present study showed cytotoxic activity of Zyzyphus Jujube on tumor cells. Although Zyzyphus Jujube has useful compounds for medical applications.</description><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Colorimetry</subject><subject>Cytotoxicity</subject><subject>Disease prevention</subject><subject>DNA fragmentation</subject><subject>Fruits</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodialysis</subject><subject>Leukemia</subject><subject>Morphology</subject><subject>Original Research Paper</subject><subject>Phenols</subject><subject>Proteins</subject><subject>Tumor cell lines</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>0920-9069</issn><issn>1573-0778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks2KFDEUhYMoTjv6AG6kQNSNpTdJVX42AzKMfwy40Y2bkEqlptNUJWVSaWgXPovP4pOZptsZFXQVyP3uybk3B6GHGF5gAP4yYWCY1QCilpjimt1CK9xyWgPn4jZagSRQS2DyBN1LaQMAkmN6F51gCUBEI1bo28VWj1kvLvgqDJXza9e5JcRdZYfBmqXSvq_0HOYlJJdKvc_mF_x593U3r3Oq3udN7mxVbpc8hVgZO47V6LxNz0t_afrxfeuWGKo52tFNzuuin5bc7-6jO4Mek31wPE_Rp9cXH8_f1pcf3rw7f3VZm5bCUtNOFMNGSKuZNZTwDjrcWCZkM3RcWkHBYtaYxnQWpCUGYwZCGyL6vqGypafo7KA7526yvbF-iXpUc3RT8aKCdurPindrdRW2ipBWEoaLwLOjQAxfsk2Lmlzaz6m9DTkpTqngtGmbQj79L0lAMCoYK-Djv8BNyNGXNSgisSAtJo0sFD5QJoaUoh2uTWNQ-xSoQwpUSYHap0DtlR_9Pu1Nx_HbC_DkCOhk9DhE7Y1L1xwBzAWXtHDkwKVS8lc23lj89-s_Aa99zTs</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Vahedi, Fatemeh</creator><creator>Fathi Najafi, Mohsen</creator><creator>Bozari, Kazem</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080201</creationdate><title>Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study</title><author>Vahedi, Fatemeh ; Fathi Najafi, Mohsen ; Bozari, Kazem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-3b8002c89ea6ec327b0b14e6894fb79e830e164c4cbe09e2c11608ac28dd43953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Colorimetry</topic><topic>Cytotoxicity</topic><topic>Disease prevention</topic><topic>DNA fragmentation</topic><topic>Fruits</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodialysis</topic><topic>Leukemia</topic><topic>Morphology</topic><topic>Original Research Paper</topic><topic>Phenols</topic><topic>Proteins</topic><topic>Tumor cell lines</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vahedi, Fatemeh</creatorcontrib><creatorcontrib>Fathi Najafi, Mohsen</creatorcontrib><creatorcontrib>Bozari, Kazem</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cytotechnology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vahedi, Fatemeh</au><au>Fathi Najafi, Mohsen</au><au>Bozari, Kazem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study</atitle><jtitle>Cytotechnology (Dordrecht)</jtitle><stitle>Cytotechnology</stitle><addtitle>Cytotechnology</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>56</volume><issue>2</issue><spage>105</spage><epage>111</epage><pages>105-111</pages><issn>0920-9069</issn><eissn>1573-0778</eissn><abstract>In the present study, water extract of dried fruit of Zyzyphus Jujube was tested for its possible anticancer effect and induction of apoptosis on human tumor cell lines, HEp-2, HeLa and Jurkat cell lines. The inhibitory effect of water extract of this fruit on cell proliferation was assessed by MTT colorimetric assay. The induction of apoptosis of this extract was analyzed by DNA fragmentation analysis. Zyzyphus Jujube extract showed inhibitory effects on mentioned cell lines. Jurkat leukemic line was found the most sensitive cells with IC50 of 0.1 μg mL
−1
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; ProQuest Central UK/Ireland; PubMed Central; ProQuest Central |
| subjects | Apoptosis Biochemistry Biological and medical sciences Biomedicine Biotechnology Cancer Cell growth Cell proliferation Chemistry Chemistry and Materials Science Colorimetry Cytotoxicity Disease prevention DNA fragmentation Fruits Fundamental and applied biological sciences. Psychology Hemodialysis Leukemia Morphology Original Research Paper Phenols Proteins Tumor cell lines Tumor cells Tumors |
| title | Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study |
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