Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells

RhoH, a hematopoietic-specific and constitutively active member of the Rho guanosine triphosphatase (GTPase) family, has been implicated in the negative regulation of Rac GTPase-mediated signaling in hematopoietic cells. However, the molecular mechanisms underlying the functional interaction between...

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Veröffentlicht in:	Blood 2008-03, Vol.111 (5), p.2597-2605
Hauptverfasser:	Chae, Hee-Don, Lee, Katherine E., Williams, David A., Gu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Amino Acid Motifs Amino Acid Sequence Animals Biological and medical sciences Cell Membrane - enzymology Chemotaxis Cytoskeleton - metabolism Hematologic and hematopoietic diseases Hematopoiesis and Stem Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - enzymology Medical sciences Mice Mice, Inbred C57BL Molecular Sequence Data Protein Prenylation Protein Transport rac1 GTP-Binding Protein - metabolism rho GTP-Binding Proteins - chemistry rho GTP-Binding Proteins - metabolism Subcellular Fractions - enzymology Transcription Factors - chemistry Transcription Factors - metabolism
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