Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons

The impact of endocrine disrupting chemical (EDC) exposure on human health is receiving increasingly focused attention. The prototypical EDC bisphenol A (BPA) is an estrogenic high-production chemical used primarily as a monomer for the production of polycarbonate and epoxy resins. It is now well es...

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Veröffentlicht in:	Toxicology letters 2008-01, Vol.176 (2), p.149-156
Hauptverfasser:	Le, Hoa H., Carlson, Emily M., Chua, Jason P., Belcher, Scott M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Benzhydryl Compounds Biological and medical sciences BPA Endocrine disruption Cell Survival - drug effects Cells, Cultured Cerebellum - cytology Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Endocrine Disruptors - chemistry Endocrine Disruptors - metabolism Endocrine Disruptors - toxicity Enzyme-Linked Immunosorbent Assay Estradiol - pharmacology Estrogen Estrogens - toxicity Female Humans Immunochemistry L-Lactate Dehydrogenase - metabolism Medical sciences Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxicity Non-genomic Phenols - chemistry Phenols - metabolism Phenols - toxicity Polycarboxylate Cement - chemistry Product Packaging Rats Rats, Sprague-Dawley Temperature Time Factors Toxicology Water - analysis Water - chemistry
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