AR, the cell cycle, and prostate cancer

The androgen receptor (AR) is a critical effector of prostate cancer development and progression. The dependence of this tumor type on AR activity is exploited in treatment of disseminated prostate cancers, wherein ablation of AR function (achieved either through ligand depletion and/or the use of A...

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Veröffentlicht in:	Nuclear receptor signaling 2008-02, Vol.6 (1), p.e001-e001
Hauptverfasser:	Balk, Steven P, Knudsen, Karen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Androgen Receptor Antagonists Cell Cycle - drug effects Cell Cycle - physiology Cell Proliferation - drug effects Cyclin-Dependent Kinases - metabolism Genes, Tumor Suppressor Humans Male Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Phosphorylation Prostate-Specific Antigen - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - genetics Receptors, Androgen - metabolism Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Review
Online-Zugang:	Volltext
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