Crystal Structure of the Transcriptional Regulator AcrR from Escherichia coli

The AcrAB multidrug efflux pump, which belongs to the resistance nodulation division (RND) family, recognizes and extrudes a wide range of antibiotics and chemotherapeutic agents and causes the intrinsic antibiotic resistance in Escherichia coli. The expression of AcrAB is controlled by the transcri...

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Veröffentlicht in:	Journal of molecular biology 2007-11, Vol.374 (3), p.591-603
Hauptverfasser:	Li, Ming, Gu, Ruoyu, Su, Chih-Chia, Routh, Mathew D., Harris, Katherine C., Jewell, Elizabeth S., McDermott, Gerry, Yu, Edward W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites Chromatography, Gel Crystallography, X-Ray DNA Primers DNA, Bacterial - metabolism Escherichia coli Escherichia coli AcrR Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Fluorescence Polarization Ligands Models, Molecular multidrug resistance Protein Conformation Repressor Proteins - chemistry Repressor Proteins - metabolism TetR family Transcription Factors - chemistry Transcription Factors - metabolism transcriptional regulator X-ray crystallograhy
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