In vivo Evidence that Erythropoietin Protects Neurons from Ischemic Damage

Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO. EPO has been shown to protect primary cultured neurons from N-methyl-D-aspartate (NMDA) receptor-mediated g...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-04, Vol.95 (8), p.4635-4640
Hauptverfasser:	Sakanaka, Masahiro, Wen, Tong-Chun, Matsuda, Seiji, Masuda, Seiji, Morishita, Emi, Nagao, Masaya, Sasaki, Ryuzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avoidance Learning - drug effects Avoidance Learning - physiology Behavioral neuroscience Biological Sciences Brain Brain damage Cell Death - drug effects Cell Survival - drug effects Cells, Cultured Cerebral Ventricles - drug effects Cerebral Ventricles - pathology Enzymes Epics Erythropoietin - administration & dosage Erythropoietin - therapeutic use Gerbillinae Hippocampus - drug effects Hippocampus - pathology Humans Infusions, Parenteral Ischemia Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Ischemic Attack, Transient - psychology Lateral ventricles Male Medical research Nervous system Neurons Neurons - drug effects Neurons - pathology Nitric Oxide - toxicity Nitroprusside - toxicity Rats Rats, Wistar Receptors Receptors, Erythropoietin - administration & dosage Receptors, Erythropoietin - therapeutic use Recombinant Proteins - administration & dosage Recombinant Proteins - therapeutic use Synapses Vehicles
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