Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection
Abstract Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate...
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| Veröffentlicht in: | Schizophrenia research 2008-01, Vol.98 (1), p.111-117 |
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| creator | Sharma, Rajiv P Grayson, Dennis R Gavin, David P |
| description | Abstract Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia. |
| doi_str_mv | 10.1016/j.schres.2007.09.020 |
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We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2007.09.020</identifier><identifier>PMID: 17961987</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bipolar Disorder - enzymology ; Bipolar Disorder - genetics ; Bipolar Disorder - metabolism ; Databases, Genetic - statistics & numerical data ; Epigenesis, Genetic - genetics ; Female ; GAD67 expression ; Gender ; Gene Expression ; Gene Expression Profiling - statistics & numerical data ; Glutamate Decarboxylase ; HDAC enzymes ; Histone Deacetylase 1 ; Histone Deacetylases - genetics ; Histone Deacetylases - metabolism ; Humans ; Male ; Medical sciences ; Microarray ; Middle Aged ; Postmortem brain ; Prefrontal Cortex - enzymology ; Prefrontal Cortex - metabolism ; Protein Array Analysis - statistics & numerical data ; Psychiatry ; Psychology. 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Psychiatry ; Psychoses ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; RNA, Messenger ; Schizophrenia ; Schizophrenia - enzymology ; Schizophrenia - genetics ; Schizophrenia - metabolism ; Sex Factors</subject><ispartof>Schizophrenia research, 2008-01, Vol.98 (1), p.111-117</ispartof><rights>Elsevier B.V.</rights><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c612t-8c22163e310fd821293544fe9b7d9ff64254e9df71977454018330dc067c65823</citedby><cites>FETCH-LOGICAL-c612t-8c22163e310fd821293544fe9b7d9ff64254e9df71977454018330dc067c65823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2007.09.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19987476$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17961987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Rajiv P</creatorcontrib><creatorcontrib>Grayson, Dennis R</creatorcontrib><creatorcontrib>Gavin, David P</creatorcontrib><title>Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - enzymology</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar Disorder - metabolism</subject><subject>Databases, Genetic - statistics & numerical data</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Female</subject><subject>GAD67 expression</subject><subject>Gender</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling - statistics & numerical data</subject><subject>Glutamate Decarboxylase</subject><subject>HDAC enzymes</subject><subject>Histone Deacetylase 1</subject><subject>Histone Deacetylases - genetics</subject><subject>Histone Deacetylases - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microarray</subject><subject>Middle Aged</subject><subject>Postmortem brain</subject><subject>Prefrontal Cortex - enzymology</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Protein Array Analysis - statistics & numerical data</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>RNA, Messenger</subject><subject>Schizophrenia</subject><subject>Schizophrenia - enzymology</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - metabolism</subject><subject>Sex Factors</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFuEzEQhlcIREPhDRDyBW4JY693veaAVEqhSBUcgLPleGeJ042d2k7V9GF4ViZKRIALJ1ua__9mPL-r6jmHGQfevl7OslskzDMBoGagZyDgQTXhjaqnogH9sJqAFjDVupUn1ZOclwDAG1CPqxOudMt1pybVz0ufSwzIerSubEebkXGGd2siZx8D85n54BJSoacbKwtkVBxSDMWOzMVU8I7FgdE0_j6uaaTgLcub-RJdyW_YWbDjNhOGNDvzZ1uIS9Z3yRLvvS12bsM1W3mXok3Jbgk6jmQm2dPq0WDHjM8O52n1_cPFt_PL6dWXj5_Oz66mruWiTDsnBG9rrDkMfSe40HUj5YB6rno9DK0UjUTdD4prpWQjgXd1Db2DVrm26UR9Wr3dc9eb-Qp7h6EkO5p18iubtiZab_6uBL8wP-KtEUTmXUuAVwdAijcbzMWsfHY4jjZg3GSjaPW1loqEci-k1-ZMi_zdhIPZBWuWZh-s2QVrQBsKlmwv_hzwaDokSYKXB4HNzo5DssH5fNRpEknVHl-KtM5bj4m6eQwOe59o56aP_n-T_Atwow-eel7jFvMybhKlmw03WRgwX3efcPcHQQFI0XX1L1J63Ak</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Sharma, Rajiv P</creator><creator>Grayson, Dennis R</creator><creator>Gavin, David P</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080101</creationdate><title>Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection</title><author>Sharma, Rajiv P ; Grayson, Dennis R ; Gavin, David P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c612t-8c22163e310fd821293544fe9b7d9ff64254e9df71977454018330dc067c65823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - enzymology</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar Disorder - metabolism</topic><topic>Databases, Genetic - statistics & numerical data</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Female</topic><topic>GAD67 expression</topic><topic>Gender</topic><topic>Gene Expression</topic><topic>Gene Expression Profiling - statistics & numerical data</topic><topic>Glutamate Decarboxylase</topic><topic>HDAC enzymes</topic><topic>Histone Deacetylase 1</topic><topic>Histone Deacetylases - genetics</topic><topic>Histone Deacetylases - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microarray</topic><topic>Middle Aged</topic><topic>Postmortem brain</topic><topic>Prefrontal Cortex - enzymology</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Protein Array Analysis - statistics & numerical data</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>RNA, Messenger</topic><topic>Schizophrenia</topic><topic>Schizophrenia - enzymology</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - metabolism</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Rajiv P</creatorcontrib><creatorcontrib>Grayson, Dennis R</creatorcontrib><creatorcontrib>Gavin, David P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Rajiv P</au><au>Grayson, Dennis R</au><au>Gavin, David P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>98</volume><issue>1</issue><spage>111</spage><epage>117</epage><pages>111-117</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17961987</pmid><doi>10.1016/j.schres.2007.09.020</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Age Age Factors Aged Aged, 80 and over Biological and medical sciences Bipolar Disorder - enzymology Bipolar Disorder - genetics Bipolar Disorder - metabolism Databases, Genetic - statistics & numerical data Epigenesis, Genetic - genetics Female GAD67 expression Gender Gene Expression Gene Expression Profiling - statistics & numerical data Glutamate Decarboxylase HDAC enzymes Histone Deacetylase 1 Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Male Medical sciences Microarray Middle Aged Postmortem brain Prefrontal Cortex - enzymology Prefrontal Cortex - metabolism Protein Array Analysis - statistics & numerical data Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger Schizophrenia Schizophrenia - enzymology Schizophrenia - genetics Schizophrenia - metabolism Sex Factors |
| title | Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection |
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