Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens

Abstract The viral strain responsible for smallpox infection is variola major (VARV). As a result of the successful eradication of smallpox with the vaccinia virus (VACV), the general population is no longer required to receive a smallpox vaccine, and will have no protection against smallpox. This l...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2008-02, Vol.371 (1), p.98-107
Hauptverfasser:	Sakhatskyy, Pavlo, Wang, Shixia, Zhang, Chuanyou, Chou, Te-Hui, Kishko, Michael, Lu, Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, Viral - genetics Antigens, Viral - immunology Body Weight Cell Line Chemoprevention - methods Enzyme-Linked Immunosorbent Assay Escherichia coli - genetics Feasibility Studies Female Humans Immunization Schedule Immunoglobulin G - blood Immunoglobulin G - immunology Infectious Disease Kidney - cytology Mice Mice, Inbred BALB C Models, Animal Molecular Sequence Data Neutralization Tests Poxvirus Sequence Homology, Amino Acid Smallpox Smallpox - immunology Smallpox - prevention & control Smallpox Vaccine - administration & dosage Smallpox Vaccine - genetics Smallpox Vaccine - immunology Subunit vaccine Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, Subunit - immunology Vaccinia virus Vaccinia virus - immunology Variola Variola major Variola virus - genetics Variola virus - immunology Variola virus - pathogenicity Viral Vaccines
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