The influence of phospholipid membranes on bovine calcitonin secondary structure and amyloid formation

Calcitonin, a peptide hormone associated with medullary carcinoma of the thyroid, has the potential to form amyloid fibrils and may be a valuable model for investigating the role of peptide–membrane interactions in β‐sheet and amyloid formation. Via a new model peptide system, bovine calcitonin, we...

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Veröffentlicht in:	Protein science 2005-06, Vol.14 (6), p.1419-1428
Hauptverfasser:	Wang, Steven S.‐S., Good, Theresa A., Rymer, Dawn L.
Format:	Artikel
Sprache:	eng
Schlagworte:	amyloid Amyloid - chemistry Animals Aβ, β‐amyloid calcitonin Calcitonin - chemistry Cattle CD, circular dichroism DMPG, dimyristoylphosphatidylglycerol DOPS, 1,2‐dioleoylsn‐glycero‐3‐[phospho‐L‐serine] DPPC, 1,2‐dipalmytoyl‐sn‐glycero‐3‐phosphocholine DPPE, 1,2‐dipalmytoyl‐sn‐glycero‐3‐phosphoethanolamine HFIP, 1,1,1,3,3,3‐hexafluoro‐2‐propanol Membranes, Artificial PBS, phosphate buffered saline phospholipid membranes Phospholipids - chemistry Protein Structure, Secondary secondary structure TFA, trifluoroactic acid TFE, 1,1,1‐trifluoroethanol
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