Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines

Activation of T lymphocytes in the absence of a costimulatory signal can result in anergy or apoptotic cell death. Two molecules capable of providing a costimulatory signal, B7-1 (CD80) and B7-2 (CD86), have been shown to augment the immunogenicity of whole-tumor cell vaccines. To explore a potentia...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-06, Vol.56 (12), p.2832-2836
Hauptverfasser:	CHAMBERLAIN, R. S, CARROLL, M. W, BRONTE, V, HWU, P, WARREN, S, YANG, J. C, NISHIMURA, M, MOSS, B, ROSENBERG, S. A, RESTIFO, N. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology Antigens, CD - metabolism Antigens, Neoplasm - immunology Antineoplastic agents B7-1 Antigen - immunology B7-1 Antigen - metabolism B7-2 Antigen beta-Galactosidase - immunology Biological and medical sciences Female Immunotherapy Immunotherapy, Active Lung Neoplasms - prevention & control Lung Neoplasms - secondary Medical sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Pharmacology. Drug treatments Survival Analysis Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Vaccinia virus - immunology Vaccinia virus - metabolism Viral Vaccines - immunology
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