Transforming growth factor α and epidermal growth factor levels in normal human gastrointestinal mucosa
Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were fou...
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| Veröffentlicht in: | British journal of cancer 1989-11, Vol.60 (5), p.657-660 |
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| container_title | British journal of cancer |
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| creator | Cartlidge, SA Elder, JB |
| description | Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated. |
| doi_str_mv | 10.1038/bjc.1989.334 |
| format | Article |
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All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1989.334</identifier><identifier>PMID: 2803941</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aminoacids, peptides. Hormones. 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All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated.</description><subject>Adult</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Epidermal Growth Factor - analysis</subject><subject>experimental-oncology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Mucosa - analysis</subject><subject>Humans</subject><subject>Intestinal Mucosa - analysis</subject><subject>Male</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Proteins</subject><subject>Radioimmunoassay</subject><subject>Reference Values</subject><subject>Transforming Growth Factors - analysis</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uGyEURlHVKnXS7rKtxKZZZRxgfoBNpSpK0kqRsknX6BrfGWPNgAszqfpYfZE8U3BtOU2krhB8Rx8XDiGnnM05K9XFYm3nXCs9L8vqDZnxuhQFV0K-JTPGmCyYFuw9OU5pnbeaKXlEjoRipa74jKzuI_jUhjg439Euhl_jirZgxxDp4x8Kfklx45YYB-hfxT0-YJ-o89SHv_FqGsDTDtIYg_MjptH5fDxMNiT4QN610Cf8uF9PyI_rq_vLb8Xt3c33y6-3ha2kGAtbtgqUErouNSrWKKwlY9hYq1rV4KLWHHQlULRqWSHWDWrg0i50wxsOXJcn5MuudzMtBlxa9GOE3myiGyD-NgGceZl4tzJdeDBC5AGUzAVn-4IYfk75EWZwyWLfg8cwJSO1kJmsM3i-A20MKUVsD5dwZrZmTDZjtmZMNpPxT_8OdoD3KnL-eZ9DstC32Yt16blTV7WWoslcseNSjnyH0azDFPNHp__dS3e8h3GKeCjM0JbZIk-xqbRJ</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Cartlidge, SA</creator><creator>Elder, JB</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19891101</creationdate><title>Transforming growth factor α and epidermal growth factor levels in normal human gastrointestinal mucosa</title><author>Cartlidge, SA ; Elder, JB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-c3f8a8829539e8068e5700e6cc8f86eb591a942e2f8d4ee56e9a17cb96161a193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Epidermal Growth Factor - analysis</topic><topic>experimental-oncology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Mucosa - analysis</topic><topic>Humans</topic><topic>Intestinal Mucosa - analysis</topic><topic>Male</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Proteins</topic><topic>Radioimmunoassay</topic><topic>Reference Values</topic><topic>Transforming Growth Factors - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cartlidge, SA</creatorcontrib><creatorcontrib>Elder, JB</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cartlidge, SA</au><au>Elder, JB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming growth factor α and epidermal growth factor levels in normal human gastrointestinal mucosa</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>60</volume><issue>5</issue><spage>657</spage><epage>660</epage><pages>657-660</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>2803941</pmid><doi>10.1038/bjc.1989.334</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Adult Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Epidermal Growth Factor - analysis experimental-oncology Female Fundamental and applied biological sciences. Psychology Gastric Mucosa - analysis Humans Intestinal Mucosa - analysis Male Molecular Medicine Oncology Proteins Radioimmunoassay Reference Values Transforming Growth Factors - analysis |
| title | Transforming growth factor α and epidermal growth factor levels in normal human gastrointestinal mucosa |
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