The prognostic influence of serum neuron specific enolase in small cell lung cancer
An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum l...
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| Veröffentlicht in: | British journal of cancer 1988-12, Vol.58 (6), p.805-807 |
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| creator | JØRGENSEN, L. G. M ØSTERLIND, K HANSEN, H. H COOPER, E. H |
| description | An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum lactate dehydrogenase (LDH), neuron specific enolase (NSE), alpha-1-acid glycoprotein and plasma sodium. Multivariate analysis, taking stage of disease into account, resulted in selection of PS and NSE as the most influential of the investigated variables. LDH was excluded as an independent prognosticator, but there was a strong correlation between the influence of LDH and NSE (coefficient: -0.38) as well as between their serum concentrations (coefficient: 0.72). LDH and NSE apparently have similar prognostic influence, and NSE seems superior to LDH. A firm conclusion should, however, await our investigation of a large series of patients. |
| doi_str_mv | 10.1038/bjc.1988.313 |
| format | Article |
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LDH was excluded as an independent prognosticator, but there was a strong correlation between the influence of LDH and NSE (coefficient: -0.38) as well as between their serum concentrations (coefficient: 0.72). LDH and NSE apparently have similar prognostic influence, and NSE seems superior to LDH. 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G. M</creatorcontrib><creatorcontrib>ØSTERLIND, K</creatorcontrib><creatorcontrib>HANSEN, H. H</creatorcontrib><creatorcontrib>COOPER, E. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JØRGENSEN, L. G. M</au><au>ØSTERLIND, K</au><au>HANSEN, H. H</au><au>COOPER, E. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic influence of serum neuron specific enolase in small cell lung cancer</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>58</volume><issue>6</issue><spage>805</spage><epage>807</epage><pages>805-807</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum lactate dehydrogenase (LDH), neuron specific enolase (NSE), alpha-1-acid glycoprotein and plasma sodium. Multivariate analysis, taking stage of disease into account, resulted in selection of PS and NSE as the most influential of the investigated variables. LDH was excluded as an independent prognosticator, but there was a strong correlation between the influence of LDH and NSE (coefficient: -0.38) as well as between their serum concentrations (coefficient: 0.72). LDH and NSE apparently have similar prognostic influence, and NSE seems superior to LDH. A firm conclusion should, however, await our investigation of a large series of patients.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>2852029</pmid><doi>10.1038/bjc.1988.313</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Biomarkers, Tumor - blood Carcinoembryonic Antigen - metabolism Carcinoma, Small Cell - enzymology Female Humans L-Lactate Dehydrogenase - blood Lung Neoplasms - enzymology Male Medical sciences Middle Aged Orosomucoid - blood Phosphopyruvate Hydratase - blood Pneumology Prognosis Sodium - blood Tumors of the respiratory system and mediastinum |
| title | The prognostic influence of serum neuron specific enolase in small cell lung cancer |
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