BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours
BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical stai...
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| Veröffentlicht in: | British journal of cancer 2008-02, Vol.98 (3), p.571-579 |
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| creator | D'Arcy, V Pore, N Docquier, F Abdullaev, Z K Chernukhin, I Kita, G-X Rai, S Smart, M Farrar, D Pack, S Lobanenkov, V Klenova, E |
| description | BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT–PCR analyses and (2) assess potential correlation between BORIS levels in tumours with clinical/pathological parameters. BORIS was detected in all 18 inspected breast cell lines, but not in a primary normal breast cell culture. In 70.7% (41 of 58 cases) BORIS was observed in breast tumours. High levels of BORIS correlated with high levels of progesterone receptor (PR) and oestrogen receptor (ER). The link between BORIS and PR/ER was further confirmed by the ability of BORIS to activate the promoters of the
PR
and
ER
genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the
RP
and
ER
genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours. |
| doi_str_mv | 10.1038/sj.bjc.6604181 |
| format | Article |
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PR
and
ER
genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the
RP
and
ER
genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6604181</identifier><identifier>PMID: 18195709</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antigens ; Biological and medical sciences ; Biomarkers ; Biomarkers, Tumor - analysis ; Biomedical and Life Sciences ; Biomedicine ; Breast - metabolism ; Breast cancer ; Breast Neoplasms - metabolism ; Cancer Research ; Cell Line, Tumor ; Cells, Cultured ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drug Resistance ; Epidemiology ; Gene Expression ; Genes ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Mammary gland diseases ; Medical research ; Medical sciences ; Molecular Diagnostics ; Molecular Medicine ; Oncology ; Promoter Regions, Genetic ; Proteins ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Surgery ; Transcription factors ; Tumors</subject><ispartof>British journal of cancer, 2008-02, Vol.98 (3), p.571-579</ispartof><rights>The Author(s) 2008</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Feb 12, 2008</rights><rights>Copyright © 2008 Cancer Research UK 2008 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-7ec9eb751345fb90cced86402a32590d5549b73c3343e913bdc0d1eba86573143</citedby><cites>FETCH-LOGICAL-c516t-7ec9eb751345fb90cced86402a32590d5549b73c3343e913bdc0d1eba86573143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243163/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243163/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20144687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18195709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Arcy, V</creatorcontrib><creatorcontrib>Pore, N</creatorcontrib><creatorcontrib>Docquier, F</creatorcontrib><creatorcontrib>Abdullaev, Z K</creatorcontrib><creatorcontrib>Chernukhin, I</creatorcontrib><creatorcontrib>Kita, G-X</creatorcontrib><creatorcontrib>Rai, S</creatorcontrib><creatorcontrib>Smart, M</creatorcontrib><creatorcontrib>Farrar, D</creatorcontrib><creatorcontrib>Pack, S</creatorcontrib><creatorcontrib>Lobanenkov, V</creatorcontrib><creatorcontrib>Klenova, E</creatorcontrib><title>BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT–PCR analyses and (2) assess potential correlation between BORIS levels in tumours with clinical/pathological parameters. BORIS was detected in all 18 inspected breast cell lines, but not in a primary normal breast cell culture. In 70.7% (41 of 58 cases) BORIS was observed in breast tumours. High levels of BORIS correlated with high levels of progesterone receptor (PR) and oestrogen receptor (ER). The link between BORIS and PR/ER was further confirmed by the ability of BORIS to activate the promoters of the
PR
and
ER
genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the
RP
and
ER
genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours.</description><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer Research</subject><subject>Cell Line, Tumor</subject><subject>Cells, Cultured</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mammary gland diseases</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Surgery</subject><subject>Transcription factors</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c9rFDEUB_Agil2rV48SBD3tbPNzMrkUdLFaKBS0nkMm82Y7w-xkzZsR-98b2aFVQTyFkE9eXt6XkJecbTiT1Rn2m7oPm7Jkilf8EVlxLUXBK2EekxVjzBTMCnZCniH2eWtZZZ6Sk0ytNsyuiHt__fnyy5p6evDJD3E3A40tnW6BTsmPGFJ3mLo40taHKaY13d5sL9a0Q-prSFlMwx2FH4cEiNDQbqR1Ao8TneZ9nBM-J09aPyC8WNZT8vXiw832U3F1_fFy--6qCJqXU2EgWKiN5lLptrYsBGiqUjHhpdCWNVorWxsZpFQSLJd1E1jDofZVqY3kSp6S82Pdw1zvoQkw5vYHd0jd3qc7F33n_jwZu1u3i9-dEEryUuYCb5cCKX6bASe37zDAMPgR4ozOMGGU5dV_oWClLrnSGb7-C_Z5ImOeQn7UWiOZERltjiikiJigvW-ZM_crYYe9ywm7JeF84dXvH33gS6QZvFmAx-CHNmcUOrx3gnGlyspkd3Z0mI_GHaSH9v7x9E8zn76o</recordid><startdate>20080212</startdate><enddate>20080212</enddate><creator>D'Arcy, V</creator><creator>Pore, N</creator><creator>Docquier, F</creator><creator>Abdullaev, Z K</creator><creator>Chernukhin, I</creator><creator>Kita, G-X</creator><creator>Rai, S</creator><creator>Smart, M</creator><creator>Farrar, D</creator><creator>Pack, S</creator><creator>Lobanenkov, V</creator><creator>Klenova, E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080212</creationdate><title>BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours</title><author>D'Arcy, V ; Pore, N ; Docquier, F ; Abdullaev, Z K ; Chernukhin, I ; Kita, G-X ; Rai, S ; Smart, M ; Farrar, D ; Pack, S ; Lobanenkov, V ; Klenova, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-7ec9eb751345fb90cced86402a32590d5549b73c3343e913bdc0d1eba86573143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cancer Research</topic><topic>Cell Line, Tumor</topic><topic>Cells, Cultured</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mammary gland diseases</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Surgery</topic><topic>Transcription factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'Arcy, V</creatorcontrib><creatorcontrib>Pore, N</creatorcontrib><creatorcontrib>Docquier, F</creatorcontrib><creatorcontrib>Abdullaev, Z K</creatorcontrib><creatorcontrib>Chernukhin, I</creatorcontrib><creatorcontrib>Kita, G-X</creatorcontrib><creatorcontrib>Rai, S</creatorcontrib><creatorcontrib>Smart, M</creatorcontrib><creatorcontrib>Farrar, D</creatorcontrib><creatorcontrib>Pack, S</creatorcontrib><creatorcontrib>Lobanenkov, V</creatorcontrib><creatorcontrib>Klenova, E</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'Arcy, V</au><au>Pore, N</au><au>Docquier, F</au><au>Abdullaev, Z K</au><au>Chernukhin, I</au><au>Kita, G-X</au><au>Rai, S</au><au>Smart, M</au><au>Farrar, D</au><au>Pack, S</au><au>Lobanenkov, V</au><au>Klenova, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2008-02-12</date><risdate>2008</risdate><volume>98</volume><issue>3</issue><spage>571</spage><epage>579</epage><pages>571-579</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT–PCR analyses and (2) assess potential correlation between BORIS levels in tumours with clinical/pathological parameters. BORIS was detected in all 18 inspected breast cell lines, but not in a primary normal breast cell culture. In 70.7% (41 of 58 cases) BORIS was observed in breast tumours. High levels of BORIS correlated with high levels of progesterone receptor (PR) and oestrogen receptor (ER). The link between BORIS and PR/ER was further confirmed by the ability of BORIS to activate the promoters of the
PR
and
ER
genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the
RP
and
ER
genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18195709</pmid><doi>10.1038/sj.bjc.6604181</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antigens Biological and medical sciences Biomarkers Biomarkers, Tumor - analysis Biomedical and Life Sciences Biomedicine Breast - metabolism Breast cancer Breast Neoplasms - metabolism Cancer Research Cell Line, Tumor Cells, Cultured DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance Epidemiology Gene Expression Genes Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Mammary gland diseases Medical research Medical sciences Molecular Diagnostics Molecular Medicine Oncology Promoter Regions, Genetic Proteins Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Surgery Transcription factors Tumors |
| title | BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours |
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