Cardiac capsaicin‐sensitive sensory nerves regulate myocardial relaxation via S‐nitrosylation of SERCA: role of peroxynitrite

Background and purpose: Sensory neuropathy develops in the presence of cardiovascular risk factors (e.g. diabetes, dyslipidemia), but its pathological consequences in the heart are unclear. We have previously shown that systemic sensory chemodenervation by capsaicin leads to impaired myocardial rela...

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Veröffentlicht in:	British journal of pharmacology 2008-02, Vol.153 (3), p.488-496
Hauptverfasser:	Bencsik, P, Kupai, K, Giricz, Z, Görbe, A, Huliák, I, Fürst, S, Dux, L, Csont, T, Jancsó, G, Ferdinandy, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism capsaicin Capsaicin - pharmacology free radicals Male Medical sciences myocardial function Myocardium - metabolism Neurons, Afferent - drug effects Neurons, Afferent - metabolism nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III - drug effects Nitric Oxide Synthase Type III - metabolism peroxynitrite Peroxynitrous Acid - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Research Papers RNA, Messenger - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - drug effects Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism sensory nerves SERCA Superoxide Dismutase - drug effects Superoxide Dismutase - metabolism S‐nitrosylation Ventricular Function, Left - drug effects
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