A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism

By proposing TSH as a key negative regulator of bone turnover, recent studies in TSH receptor (TSHR) null mice challenged the established view that skeletal responses to disruption of the hypothalamic-pituitary-thyroid axis result from altered thyroid hormone (T3) action in bone. Importantly, this h...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2008-02, Vol.22 (2), p.501-512
Hauptverfasser:	Bassett, J. H. Duncan, Williams, Allan J, Murphy, Elaine, Boyde, Alan, Howell, Peter G. T, Swinhoe, Rowan, Archanco, Marta, Flamant, Frédéric, Samarut, Jacques, Costagliola, Sabine, Vassart, Gilbert, Weiss, Roy E, Refetoff, Samuel, Williams, Graham R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Bone and Bones - abnormalities Bone and Bones - metabolism Bone Development - drug effects Bone Development - genetics Bone Development - physiology Bone Remodeling - drug effects Bone Remodeling - genetics Bone Remodeling - physiology Calcification, Physiologic - drug effects Calcification, Physiologic - genetics Calcification, Physiologic - physiology Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - physiology Cells, Cultured Cyclic AMP - metabolism Hypothyroidism - blood Hypothyroidism - genetics Hypothyroidism - pathology In Situ Hybridization Mice Mice, Knockout Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects Osteogenesis - physiology Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Paired Box Transcription Factors - physiology PAX8 Transcription Factor Reverse Transcriptase Polymerase Chain Reaction Thyroid Gland - metabolism Thyroid Hormones - blood Thyroid Hormones - pharmacology Thyrotropin - blood
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