IL-2– and IL-15–induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes

We examined functional status, activation mechanisms, and biologic role of the mTORC1 signaling pathway in malignant CD4+ T cells derived from the cutaneous T-cell lymphoma (CTCL). Whereas the spontaneously growing CTCL-derived cell lines displayed persistent activation of the TORC1 as well as the P...

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Veröffentlicht in:	Blood 2008-02, Vol.111 (4), p.2181-2189
Hauptverfasser:	Marzec, Michal, Liu, Xiaobin, Kasprzycka, Monika, Witkiewicz, Agnieszka, Raghunath, Puthiyaveettil N., El-Salem, Mouna, Robertson, Erle, Odum, Niels, Wasik, Mariusz A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell Line, Tumor Cytokines - pharmacology Humans Interleukin-15 - pharmacology Interleukin-2 - pharmacology Lymphoma, T-Cell, Cutaneous - immunology Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes Neoplasia Proteins Recombinant Proteins - pharmacology RNA, Small Interfering - genetics Sirolimus - pharmacology TOR Serine-Threonine Kinases Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured
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