Changes in force and cytosolic Ca2+ concentration after length changes in isolated rat ventricular trabeculae

Changes in cytosolic [Ca 2+ ] ([Ca 2+ ] i ) were measured in isolated rat trabeculae that had been micro-injected with fura-2 salt, in order to investigate the mechanism by which twitch force changes following an alteration of muscle length. A step increase in length of the muscle produced a rapid p...

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Veröffentlicht in:	The Journal of physiology 1998-01, Vol.506 (2), p.431-444
Hauptverfasser:	Kentish, Jonathan C., Wrzosek, Antoni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium - pharmacology Cytosol - chemistry Diastole - physiology Elasticity Fluorescent Dyes - pharmacology Fura-2 - pharmacology Heart Ventricles - cytology Male Membrane Potentials - physiology Muscle Fibers, Fast-Twitch - physiology Muscle Fibers, Skeletal - physiology Muscle Fibers, Slow-Twitch - physiology Myocardial Contraction - physiology Myofibrils - physiology Original Papillary Muscles - physiology Rats Rats, Wistar Sarcoplasmic Reticulum - chemistry Sarcoplasmic Reticulum - physiology Space life sciences Systole - physiology Ventricular Function
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