The NECAP PHear domain increases clathrin accessory protein binding potential

AP‐2 is a key regulator of the endocytic protein machinery driving clathrin‐coated vesicle (CCV) formation. One critical function, mediated primarily by the AP‐2 α‐ear, is the recruitment of accessory proteins. NECAPs are α‐ear‐binding proteins that enrich on CCVs. Here, we have solved the structure...

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