Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

Thyroid hormone is a critical determinant of cellular metabolism and differentiation. Precise tissue-specific regulation of the active ligand 3,5,3'-triiodothyronine (T3) is achieved by the sequential removal of iodine groups from the thyroid hormone molecule, with type 3 deiodinase (D3) compri...

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Veröffentlicht in:	The Journal of clinical investigation 2008-03, Vol.118 (3), p.975-983
Hauptverfasser:	Simonides, Warner S, Mulcahey, Michelle A, Redout, Everaldo M, Muller, Alice, Zuidwijk, Marian J, Visser, Theo J, Wassen, Frank W J S, Crescenzi, Alessandra, da-Silva, Wagner S, Harney, John, Engel, Felix B, Obregon, Maria-Jesús, Larsen, P Reed, Bianco, Antonio C, Huang, Stephen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Cardiomyocytes Care and treatment Critically ill Enzyme Induction Fibroblasts Genetic aspects Health aspects Hormones Hypertrophy, Right Ventricular - metabolism Hypothyroidism Hypoxia Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - physiology Illnesses Iodide Peroxidase - physiology Ischemia Ischemia - metabolism Male Medical examination Metabolism Metabolites Physiological aspects Rats Rats, Wistar Risk factors Signal Transduction Thyroid gland Thyroid hormones Thyroid Hormones - metabolism Triiodothyronine - physiology
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