RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe

Sister chromatid cohesion is established during S phase near the replication fork. However, how DNA replication is coordinated with chromosomal cohesion pathway is largely unknown. Here, we report studies of fission yeast Ctf18, a subunit of the RFC(Ctf18) replication factor C complex, and Chl1, a p...

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Veröffentlicht in:	Molecular biology of the cell 2008-02, Vol.19 (2), p.595-607
Hauptverfasser:	Ansbach, Alison B, Noguchi, Chiaki, Klansek, Ian W, Heidlebaugh, Mike, Nakamura, Toru M, Noguchi, Eishi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation - drug effects Alkylation - radiation effects Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatin - metabolism DNA Damage DNA Replication - drug effects DNA Replication - radiation effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Activation - drug effects Enzyme Activation - radiation effects Hydroxyurea - pharmacology Microbial Viability - drug effects Microbial Viability - radiation effects Models, Biological Mutation - genetics Protein Binding - drug effects Protein Binding - radiation effects Protein Transport - drug effects Protein Transport - radiation effects Replication Protein C - metabolism S Phase - drug effects S Phase - radiation effects Schizosaccharomyces - cytology Schizosaccharomyces - drug effects Schizosaccharomyces - enzymology Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Sister Chromatid Exchange - drug effects Sister Chromatid Exchange - radiation effects Ultraviolet Rays
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