Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1

Presenilins 1 (PS1) and 2 (PS2) are multispanning transmembrane proteins associated with familial Alzheimer disease (FAD). They are developmentally regulated, being expressed at highest levels during neuronal differentiation and are sustained at a lower level throughout life. We investigated the dis...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 1999-08, Vol.5 (8), p.542-554
Hauptverfasser:	Lévesque, L, Annaert, W, Craessaerts, K, Mathews, P M, Seeger, M, Nixon, R A, Van Leuven, F, Gandy, S, Westaway, D, St George-Hyslop, P, De Strooper, B, Fraser, P E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Alzheimer Disease - genetics Amino Acid Substitution Animals Gene Expression Regulation, Developmental Hippocampus - growth & development Hippocampus - metabolism Humans Membrane Proteins - genetics Mice Mice, Transgenic Neurons - metabolism Point Mutation Presenilin-1 Subcellular Fractions - metabolism
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