Engagement of tumor necrosis factor mRNA by an endotoxin-inducible cytoplasmic protein

Tumor necrosis factor (TNF) production by macrophages plays an important role in the host response to infection. TNF-alpha gene expression in RAW 264.7 macrophages is predominantly regulated at the translational level. A key element in this regulation is an AU-rich (AUR) sequence located in the 3�...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 1996-07, Vol.2 (4), p.479-488
Hauptverfasser:	Gueydan, C, Houzet, L, Marchant, A, Sels, A, Huez, G, Kruys, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Benzoquinones Cytoplasm - chemistry Electrophoresis, Polyacrylamide Gel Kinetics Lactams, Macrocyclic Macrophages - drug effects Macrophages - metabolism Mice Molecular Sequence Data Protein-Tyrosine Kinases - antagonists & inhibitors Proteins - metabolism Quinones - pharmacology Rifabutin - analogs & derivatives RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - genetics Ultraviolet Rays
Online-Zugang:	Volltext
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