Slow inactivation of L-type calcium current distorts the measurement of L- and T-type calcium current in Purkinje myocytes

We have examined slow inactivation of L-type calcium current in canine Purkinje myocytes with the whole cell patch clamp technique. Slow inactivation is voltage dependent. It is negligible at -50 mV but can inactivate more than half of available iCaL at -10 mV. There are two major consequences of th...

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