Palytoxin induces an increase in the cation conductance of red cells

Palytoxin (PTX), isolated from the marine soft coral Palythoa tuberculosa, increases the cation conductance of human red cell membranes. In the presence of 10(-10) M PTX and 10(-5) M DIDS, the membrane potential approximates the equilibrium potential for Na+ or K+ rather than Cl-. Even in the absenc...

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Veröffentlicht in:	The Journal of general physiology 1991-11, Vol.98 (5), p.969-985
Hauptverfasser:	TOSTESON, M. T, HALPERIN, J. A, KISHI, Y, TOSTESON, D. C
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid - analogs & derivatives 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid - pharmacology Acrylamides Adenosine Triphosphate - metabolism Animal poisons toxicology. Antivenoms aquatic drugs Biological and medical sciences biological poisons Biological Transport - drug effects Biological Transport - physiology cations Cesium - pharmacokinetics Chlorides - pharmacokinetics Cnidarian Venoms - pharmacology conductance coral Electric Conductivity - drug effects Electric Conductivity - physiology erythrocytes Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - physiology Humans Hydrogen-Ion Concentration Hydrolysis - drug effects induction Lithium - pharmacokinetics Magnesium - pharmacokinetics man Marine Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Palythoa tuberculosa palytoxin Potassium - pharmacokinetics Potassium Channels - drug effects Rubidium - pharmacokinetics Sodium - pharmacokinetics Sodium Channels - drug effects Sodium-Potassium-Exchanging ATPase - drug effects Time Factors toxicity Toxicology Vanadates - pharmacology
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