Coordinated regulation of Na/H exchange and [K-C] cotransport in dog red cells
Swelling-activated [K-Cl] cotransport and shrinkage-activated Na/H exchange were studied in dog red cells with altered internal Mg or Li content. The two pathways responded in a coordinated fashion. When cells were depleted of Mg, [K-Cl] cotransport was stimulated and Na/H exchange was inhibited. Ra...
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| Veröffentlicht in: | The Journal of general physiology 1990-12, Vol.96 (6), p.1141-1152 |
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| container_title | The Journal of general physiology |
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| creator | PARKER, J. C MCMANUS, T. J STARKE, L. C GITELMAN, H. J |
| description | Swelling-activated [K-Cl] cotransport and shrinkage-activated Na/H exchange were studied in dog red cells with altered internal Mg or Li content. The two pathways responded in a coordinated fashion. When cells were depleted of Mg, [K-Cl] cotransport was stimulated and Na/H exchange was inhibited. Raising internal Mg had the opposite effect: [K-Cl] cotransport was inhibited and Na/H exchange was stimulated. Li loading, previously shown to stimulate Na/H exchange, inhibited [K-Cl] cotransport. From these reciprocal effects and from other evidence, we surmise that the regulation of Na/H exchange and [K-Cl] cotransport is conducted and coordinated by a discrete mechanism that responds to changes in cell volume and is sensitive to cytoplasmic Mg and Li concentrations. |
| doi_str_mv | 10.1085/jgp.96.6.1141 |
| format | Article |
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C ; MCMANUS, T. J ; STARKE, L. C ; GITELMAN, H. J</creator><creatorcontrib>PARKER, J. C ; MCMANUS, T. J ; STARKE, L. C ; GITELMAN, H. J</creatorcontrib><description>Swelling-activated [K-Cl] cotransport and shrinkage-activated Na/H exchange were studied in dog red cells with altered internal Mg or Li content. The two pathways responded in a coordinated fashion. When cells were depleted of Mg, [K-Cl] cotransport was stimulated and Na/H exchange was inhibited. Raising internal Mg had the opposite effect: [K-Cl] cotransport was inhibited and Na/H exchange was stimulated. Li loading, previously shown to stimulate Na/H exchange, inhibited [K-Cl] cotransport. From these reciprocal effects and from other evidence, we surmise that the regulation of Na/H exchange and [K-Cl] cotransport is conducted and coordinated by a discrete mechanism that responds to changes in cell volume and is sensitive to cytoplasmic Mg and Li concentrations.</description><identifier>ISSN: 0022-1295</identifier><identifier>EISSN: 1540-7748</identifier><identifier>DOI: 10.1085/jgp.96.6.1141</identifier><identifier>PMID: 1962814</identifier><identifier>CODEN: JGPLAD</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Animals ; Biological and medical sciences ; Calcimycin - pharmacology ; Carrier Proteins - blood ; Chlorides - blood ; Dogs ; Erythrocytes - metabolism ; Fundamental and applied biological sciences. Psychology ; K Cl- Cotransporters ; Kinetics ; Lithium - pharmacology ; Magnesium - pharmacology ; Potassium - blood ; Sodium-Hydrogen Exchangers ; Symporters ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>The Journal of general physiology, 1990-12, Vol.96 (6), p.1141-1152</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-6d6ae1d48fd84e28ae426384b576381e30ec54dbe7714b5efd49cc0c6e576e343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19359559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1962814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PARKER, J. C</creatorcontrib><creatorcontrib>MCMANUS, T. J</creatorcontrib><creatorcontrib>STARKE, L. C</creatorcontrib><creatorcontrib>GITELMAN, H. J</creatorcontrib><title>Coordinated regulation of Na/H exchange and [K-C] cotransport in dog red cells</title><title>The Journal of general physiology</title><addtitle>J Gen Physiol</addtitle><description>Swelling-activated [K-Cl] cotransport and shrinkage-activated Na/H exchange were studied in dog red cells with altered internal Mg or Li content. The two pathways responded in a coordinated fashion. When cells were depleted of Mg, [K-Cl] cotransport was stimulated and Na/H exchange was inhibited. Raising internal Mg had the opposite effect: [K-Cl] cotransport was inhibited and Na/H exchange was stimulated. Li loading, previously shown to stimulate Na/H exchange, inhibited [K-Cl] cotransport. From these reciprocal effects and from other evidence, we surmise that the regulation of Na/H exchange and [K-Cl] cotransport is conducted and coordinated by a discrete mechanism that responds to changes in cell volume and is sensitive to cytoplasmic Mg and Li concentrations.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - pharmacology</subject><subject>Carrier Proteins - blood</subject><subject>Chlorides - blood</subject><subject>Dogs</subject><subject>Erythrocytes - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>K Cl- Cotransporters</subject><subject>Kinetics</subject><subject>Lithium - pharmacology</subject><subject>Magnesium - pharmacology</subject><subject>Potassium - blood</subject><subject>Sodium-Hydrogen Exchangers</subject><subject>Symporters</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0022-1295</issn><issn>1540-7748</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtPAyEUhYnRaH0sXZqw0d1UYIBhNiam8RWNbnRlDKFwZxwzhQpTo_9emjY-2NyE83Hv5RyEDikZU6LE6Vs7H9dyLMeUcrqBRlRwUlQVV5toRAhjBWW12EG7Kb2RfAQj22ib1pIpykfofhJCdJ03AzgcoV30ZuiCx6HB9-b0GsOnfTW-BWy8w8-3xeQF2zBE49M8xAF3HrvQ5ocOW-j7tI-2GtMnOFjXPfR0efE4uS7uHq5uJud3heWVGgrppAHquGqc4sCUAc5kqfhUVLlQKAlYwd0UqormS2gcr60lVkIGoOTlHjpb9Z0vpjNwFnzeqdfz2M1M_NLBdPq_4rtX3YYPzRirSUlzg5N1gxjeF5AGPevS8gvGQ1gkrQiTJDuawWIF2hhSitD8DKFELwPQOQBdSy31MoDMH_3d7JdeOZ7147VukjV9k620XfqDlaIWoi6_AUrtjuQ</recordid><startdate>19901201</startdate><enddate>19901201</enddate><creator>PARKER, J. C</creator><creator>MCMANUS, T. J</creator><creator>STARKE, L. C</creator><creator>GITELMAN, H. J</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19901201</creationdate><title>Coordinated regulation of Na/H exchange and [K-C] cotransport in dog red cells</title><author>PARKER, J. C ; MCMANUS, T. J ; STARKE, L. C ; GITELMAN, H. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-6d6ae1d48fd84e28ae426384b576381e30ec54dbe7714b5efd49cc0c6e576e343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - pharmacology</topic><topic>Carrier Proteins - blood</topic><topic>Chlorides - blood</topic><topic>Dogs</topic><topic>Erythrocytes - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>K Cl- Cotransporters</topic><topic>Kinetics</topic><topic>Lithium - pharmacology</topic><topic>Magnesium - pharmacology</topic><topic>Potassium - blood</topic><topic>Sodium-Hydrogen Exchangers</topic><topic>Symporters</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PARKER, J. C</creatorcontrib><creatorcontrib>MCMANUS, T. J</creatorcontrib><creatorcontrib>STARKE, L. C</creatorcontrib><creatorcontrib>GITELMAN, H. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordinated regulation of Na/H exchange and [K-C] cotransport in dog red cells</atitle><jtitle>The Journal of general physiology</jtitle><addtitle>J Gen Physiol</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>96</volume><issue>6</issue><spage>1141</spage><epage>1152</epage><pages>1141-1152</pages><issn>0022-1295</issn><eissn>1540-7748</eissn><coden>JGPLAD</coden><abstract>Swelling-activated [K-Cl] cotransport and shrinkage-activated Na/H exchange were studied in dog red cells with altered internal Mg or Li content. The two pathways responded in a coordinated fashion. When cells were depleted of Mg, [K-Cl] cotransport was stimulated and Na/H exchange was inhibited. Raising internal Mg had the opposite effect: [K-Cl] cotransport was inhibited and Na/H exchange was stimulated. Li loading, previously shown to stimulate Na/H exchange, inhibited [K-Cl] cotransport. From these reciprocal effects and from other evidence, we surmise that the regulation of Na/H exchange and [K-Cl] cotransport is conducted and coordinated by a discrete mechanism that responds to changes in cell volume and is sensitive to cytoplasmic Mg and Li concentrations.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>1962814</pmid><doi>10.1085/jgp.96.6.1141</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1295 |
| ispartof | The Journal of general physiology, 1990-12, Vol.96 (6), p.1141-1152 |
| issn | 0022-1295 1540-7748 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals Biological and medical sciences Calcimycin - pharmacology Carrier Proteins - blood Chlorides - blood Dogs Erythrocytes - metabolism Fundamental and applied biological sciences. Psychology K Cl- Cotransporters Kinetics Lithium - pharmacology Magnesium - pharmacology Potassium - blood Sodium-Hydrogen Exchangers Symporters Vertebrates: blood, hematopoietic organs, reticuloendothelial system |
| title | Coordinated regulation of Na/H exchange and [K-C] cotransport in dog red cells |
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