Neutrophil Interactions with Keratocytes during Corneal Epithelial Wound Healing: A Role for CD18 Integrins

To determine the role of keratocytes and leukocyte beta(2) (CD18) integrins in neutrophil (PMN) migration through the corneal stroma after epithelial scrape injury. Using C57BL/6 wild-type and CD18(-/-) mice, corneas were excised at 6 hours (wild-type) or 24 hours (CD18(-/-)) after central corneal e...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2007-11, Vol.48 (11), p.5023-5029
Hauptverfasser:	Petrescu, Matei S, Larry, Chonna L, Bowden, Robert A, Williams, George W, Gagen, Debjani, Li, Zhijie, Smith, C. Wayne, Burns, Alan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CD18 Antigens - physiology Cell Migration Assays, Leukocyte Collagen - ultrastructure Corneal Stroma - ultrastructure Disease Models, Animal Epithelium, Corneal - injuries Epithelium, Corneal - ultrastructure Eye and associated structures. Visual pathways and centers. Vision Eye Injuries - metabolism Eye Injuries - pathology Fibroblasts - physiology Fundamental and applied biological sciences. Psychology Mice Mice, Inbred C57BL Neutrophil Infiltration - physiology Neutrophils - physiology Neutrophils - ultrastructure Vertebrates: nervous system and sense organs Wound Healing - physiology Wounds, Nonpenetrating - metabolism Wounds, Nonpenetrating - pathology
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