Platinum-DNA adduct formation in leucocytes of children in relation to pharmacokinetics after cisplatin and carboplatin therapy

Platinum (Pt)-DNA adducts were measured in peripheral blood leucocytes (PBLs) from 24 children with solid tumours after standard cisplatin and/or carboplatin treatment. The relationship between Pt-DNA adduct levels and pharmacokinetics of cisplatin and carboplatin was investigated. Adduct measuremen...

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Veröffentlicht in:	British journal of cancer 1997, Vol.76 (11), p.1466-1473
Hauptverfasser:	Peng, B, Tilby, MJ, English, MW, Price, L, Pearson, AD, Boddy, AV, Newell, DR
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Area Under Curve Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carboplatin - administration & dosage Carboplatin - pharmacokinetics Carboplatin - therapeutic use Chemotherapy Child Child, Preschool Cisplatin - administration & dosage Cisplatin - blood Cisplatin - pharmacokinetics Cisplatin - therapeutic use DNA Adducts - blood Dose-Response Relationship, Drug Drug Interactions Drug Resistance Epidemiology experimental-oncology Female Humans Infant Leukocytes - drug effects Leukocytes - metabolism Male Medical sciences Molecular Medicine Neoplasms - blood Neoplasms - drug therapy Oncology Pharmacology. Drug treatments
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