Production of Sterility in Mice by Deuterium Oxide
Some of the conditions required to produce sterility in male mice by D/ sub 2/O were investigated. Sterility can be produced in C/sub 57/ male mice by substitution of 30% D/sub 2/O for normal water in the drinking water for two weeks. The mice become sterile four weeks aftcr the initial treatment wi...
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| Veröffentlicht in: | Proc. Natl. Acad. Sci. U.S 1959-04, Vol.45 (4), p.581-586 |
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| container_title | Proc. Natl. Acad. Sci. U.S |
| container_volume | 45 |
| creator | Hughes, Ann M. Bennett, Edward L. Calvin, Melvin |
| description | Some of the conditions required to produce sterility in male mice by D/ sub 2/O were investigated. Sterility can be produced in C/sub 57/ male mice by substitution of 30% D/sub 2/O for normal water in the drinking water for two weeks. The mice become sterile four weeks aftcr the initial treatment with D/sub 2/O, and in this experiment two weeks after normal water has again been provided in the drinking water. By this and other experiments the sensitive phase of sperm production was shown to be centered around the late prophase of meiosis. It is suggested that the normal construction of the genetic material was affected and that the mechanism of action of D/sub 2/O is at the macromolecular level. (auth) |
| doi_str_mv | 10.1073/pnas.45.4.581 |
| format | Article |
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Sterility can be produced in C/sub 57/ male mice by substitution of 30% D/sub 2/O for normal water in the drinking water for two weeks. The mice become sterile four weeks aftcr the initial treatment with D/sub 2/O, and in this experiment two weeks after normal water has again been provided in the drinking water. By this and other experiments the sensitive phase of sperm production was shown to be centered around the late prophase of meiosis. It is suggested that the normal construction of the genetic material was affected and that the mechanism of action of D/sub 2/O is at the macromolecular level. (auth)</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.45.4.581</identifier><identifier>PMID: 16590419</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>BIOLOGY AND MEDICINE ; CHROMOSOMES ; Deuterium ; GONADS ; HEAVY WATER ; Mating behavior ; MEIOSIS ; MICE ; MITOSIS ; Physiology ; Potable water ; Pregnancy ; Prophase ; REPRODUCTION ; SENSITIVITY ; Spermatids ; Spermatozoa ; STERILIZATION ; STOMACH ; TESTES ; WATER</subject><ispartof>Proc. Natl. Acad. Sci. 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Natl. Acad. Sci. U.S</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Some of the conditions required to produce sterility in male mice by D/ sub 2/O were investigated. Sterility can be produced in C/sub 57/ male mice by substitution of 30% D/sub 2/O for normal water in the drinking water for two weeks. The mice become sterile four weeks aftcr the initial treatment with D/sub 2/O, and in this experiment two weeks after normal water has again been provided in the drinking water. By this and other experiments the sensitive phase of sperm production was shown to be centered around the late prophase of meiosis. It is suggested that the normal construction of the genetic material was affected and that the mechanism of action of D/sub 2/O is at the macromolecular level. (auth)</description><subject>BIOLOGY AND MEDICINE</subject><subject>CHROMOSOMES</subject><subject>Deuterium</subject><subject>GONADS</subject><subject>HEAVY WATER</subject><subject>Mating behavior</subject><subject>MEIOSIS</subject><subject>MICE</subject><subject>MITOSIS</subject><subject>Physiology</subject><subject>Potable water</subject><subject>Pregnancy</subject><subject>Prophase</subject><subject>REPRODUCTION</subject><subject>SENSITIVITY</subject><subject>Spermatids</subject><subject>Spermatozoa</subject><subject>STERILIZATION</subject><subject>STOMACH</subject><subject>TESTES</subject><subject>WATER</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><recordid>eNpVkc1v2zAMxYWhw5p2O-6yw2D00JtTkZYs69BD0X0CHTJg21mQaXlR4ViZJBfLf18HCbr1RID8PfKBj7G3wJfAVXW1HW1aCrkUS9nAC7YArqGsheYnbME5qrIRKE7ZWUr3nHMtG_6KnUItNRegFwy_x9BNlH0Yi9AXP7KLfvB5V_ix-ObJFe2u-OCmfXvaFKu_vnOv2cveDsm9OdZz9uvTx5-3X8q71eevtzd3JaGSUCrUihB6tIqswEp1yKkF3aCFineuk62gWlVtDahRStWQ7jtBXQNATlJ1zq4Pe7dTu3EduTFHO5ht9BsbdyZYb55PRr82v8ODQcSa46y_OOhDyt4k8tnRmsI4OspGYC1RVDN0eTwSw5_JpWw2PpEbBju6MCXTzM4QlJ7B8gBSDClF1z8ZAW72SZh9EkZII8ycxMy__9_9P_r4-hl4dwDuUw7xaa458KZ6BP9rjRc</recordid><startdate>19590401</startdate><enddate>19590401</enddate><creator>Hughes, Ann M.</creator><creator>Bennett, Edward L.</creator><creator>Calvin, Melvin</creator><general>National Academy of Sciences of the United States of America</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19590401</creationdate><title>Production of Sterility in Mice by Deuterium Oxide</title><author>Hughes, Ann M. ; Bennett, Edward L. ; Calvin, Melvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2751-7297c21f2a7ca4237d20cb1982a130ded5b4c673b612925578c9fd4cd811ce5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>BIOLOGY AND MEDICINE</topic><topic>CHROMOSOMES</topic><topic>Deuterium</topic><topic>GONADS</topic><topic>HEAVY WATER</topic><topic>Mating behavior</topic><topic>MEIOSIS</topic><topic>MICE</topic><topic>MITOSIS</topic><topic>Physiology</topic><topic>Potable water</topic><topic>Pregnancy</topic><topic>Prophase</topic><topic>REPRODUCTION</topic><topic>SENSITIVITY</topic><topic>Spermatids</topic><topic>Spermatozoa</topic><topic>STERILIZATION</topic><topic>STOMACH</topic><topic>TESTES</topic><topic>WATER</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, Ann M.</creatorcontrib><creatorcontrib>Bennett, Edward L.</creatorcontrib><creatorcontrib>Calvin, Melvin</creatorcontrib><creatorcontrib>Univ. of California, Berkeley</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proc. Natl. Acad. Sci. U.S</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, Ann M.</au><au>Bennett, Edward L.</au><au>Calvin, Melvin</au><aucorp>Univ. of California, Berkeley</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of Sterility in Mice by Deuterium Oxide</atitle><jtitle>Proc. Natl. Acad. Sci. U.S</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1959-04-01</date><risdate>1959</risdate><volume>45</volume><issue>4</issue><spage>581</spage><epage>586</epage><pages>581-586</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Some of the conditions required to produce sterility in male mice by D/ sub 2/O were investigated. Sterility can be produced in C/sub 57/ male mice by substitution of 30% D/sub 2/O for normal water in the drinking water for two weeks. The mice become sterile four weeks aftcr the initial treatment with D/sub 2/O, and in this experiment two weeks after normal water has again been provided in the drinking water. By this and other experiments the sensitive phase of sperm production was shown to be centered around the late prophase of meiosis. It is suggested that the normal construction of the genetic material was affected and that the mechanism of action of D/sub 2/O is at the macromolecular level. (auth)</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>16590419</pmid><doi>10.1073/pnas.45.4.581</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proc. Natl. Acad. Sci. U.S, 1959-04, Vol.45 (4), p.581-586 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | BIOLOGY AND MEDICINE CHROMOSOMES Deuterium GONADS HEAVY WATER Mating behavior MEIOSIS MICE MITOSIS Physiology Potable water Pregnancy Prophase REPRODUCTION SENSITIVITY Spermatids Spermatozoa STERILIZATION STOMACH TESTES WATER |
| title | Production of Sterility in Mice by Deuterium Oxide |
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