Enhanced performance in prediction of protein active sites with THEMATICS and support vector machines

Theoretical microscopic titration curves (THEMATICS) is a computational method for the identification of active sites in proteins through deviations in computed titration behavior of ionizable residues. While the sensitivity to catalytic sites is high, the previously reported sensitivity to catalyti...

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Veröffentlicht in:	Protein science 2008-02, Vol.17 (2), p.333-341
Hauptverfasser:	Tong, Wenxu, Williams, Ronald J., Wei, Ying, Murga, Leonel F., Ko, Jaeju, Ondrechen, Mary Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Binding Sites Catalysis Catalytic Domain Computational Biology - methods Enzymes - chemistry functional genomics Models, Molecular Protein Conformation Proteins - chemistry Sensitivity and Specificity site prediction Software SVM THEMATICS
Online-Zugang:	Volltext
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