In vivo effects of CB2 receptor‐selective cannabinoids on the vasculature of normal and arthritic rat knee joints

Background and purpose: Cannabinoids (CBs) are known to be vasoactive and to regulate tissue inflammation. The present study examined the in vivo vasomotor effects of the CB2 receptor agonists JWH015 and JWH133 in rat knee joints. The effect of acute and chronic joint inflammation on CB2 receptor‐me...

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Veröffentlicht in:	British journal of pharmacology 2008-01, Vol.153 (2), p.358-366
Hauptverfasser:	McDougall, J J, Yu, V, Thomson, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals arthritis Arthritis, Experimental - physiopathology blood flow Blood Pressure - drug effects cannabinoids Cannabinoids - administration & dosage Cannabinoids - pharmacology cardiovascular system CB2 receptor Dose-Response Relationship, Drug Edema - drug therapy Edema - pathology endocannabinoids Image Processing, Computer-Assisted Joints - blood supply Joints - drug effects knee joint laser doppler imaging Male Rats Rats, Wistar Receptor, Cannabinoid, CB2 - drug effects Regional Blood Flow - drug effects Research Papers transient potential vanilloid receptor TRPV Cation Channels - genetics Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
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