role for T cell-derived interleukin 22 in psoriatic skin inflammation

Interleukin (IL)-22 is a T cell-derived cytokine that has been reported recently to induce cutaneous inflammation in an experimental murine model of psoriasis, and to induce in vitro an inflammatory-like phenotype. In the present study, we assessed the presence of IL-22 and the IL-22 receptor 1 (IL-...

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Veröffentlicht in:	Clinical and experimental immunology 2007-12, Vol.150 (3), p.407-415
Hauptverfasser:	Boniface, K, Guignouard, E, Pedretti, N, Garcia, M, Delwail, A, Bernard, F.-X, Nau, F, Guillet, G, Dagregorio, G, Yssel, H, Lecron, J.-C, Morel, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunology Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry Biochemistry Biochemistry, Molecular Biology Biological and medical sciences Cells, Cultured cytokines Dermatology Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Human health and pathology Humans Immunology inflammation Inflammation Mediators - metabolism Innate immunity Interleukin-22 Interleukins - biosynthesis Interleukins - genetics Interleukins - immunology Keratinocytes - immunology Life Sciences Male Middle Aged Molecular and cellular biology Molecular biophysics psoriasis Psoriasis - immunology Receptors, Interleukin - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics Skin - immunology skin disease T cells T-lymphocytes T-Lymphocytes - immunology Translational Studies Up-Regulation
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