Progesterone Receptor Membrane Component-1 (PGRMC1) Is the Mediator of Progesterone’s Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells As Revealed by PGRMC1 Small Interfering Ribonucleic Acid Treatment and Functional Analysis of PGRMC1 Mutations

Progesterone (P4) receptor membrane component-1 (PGRMC1) and its binding partner, plasminogen activator inhibitor 1 RNA binding protein (PAIRBP1) are thought to form a complex that functions as membrane receptor for P4. The present investigations confirm PGRMC1’s role in this membrane receptor compl...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2008-02, Vol.149 (2), p.534-543
Hauptverfasser:	Peluso, John J, Romak, Jonathan, Liu, Xiufang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Apoptosis - physiology Binding sites Biological and medical sciences C-Terminus Cell Line, Transformed Cell surface receptors Deletion Female Functional analysis Fundamental and applied biological sciences. Psychology Fusion protein Gene Deletion Granulosa cells Granulosa Cells - cytology Granulosa Cells - metabolism Green Fluorescent Proteins - genetics Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Mutation Plasminogen activator inhibitors Progesterone Progesterone - metabolism Protein Structure, Tertiary Proteins Rats Receptors Receptors, Progesterone - chemistry Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Ribonucleic acid RNA RNA, Small Interfering RNA-binding protein Segments siRNA Structure-Activity Relationship Transmembrane domains Tritium Vertebrates: endocrinology
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