Activation of a Cl- current by hypotonic volume increase in human endothelial cells

We have used whole-cell and perforated patches to study ionic currents induced by hypotonic extracellular solutions (HTS, 185 mOsm instead of 290 mOsm) in endothelial cells from human umbilical veins. These currents activated within 30-50 s after application of HTS, reached a maximum value after app...

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Veröffentlicht in:	The Journal of general physiology 1994-05, Vol.103 (5), p.787-805
Hauptverfasser:	NILIUS, B, OIKE, M, ZAHRADNIK, I, DROOGMANS, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acid - metabolism Arachidonic Acid - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 Biochemistry Biological and medical sciences Blood vessels and receptors Calcium - metabolism Carrier Proteins - physiology Cellular biology Chloride Channels - drug effects Chloride Channels - physiology Chlorides - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - physiology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Hypotonic Solutions Ion Pumps - physiology Ion Transport - physiology Membrane Glycoproteins - physiology Membrane Potentials - physiology Vertebrates: cardiovascular system
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