Heterologous facilitation of G protein-activated K(+) channels by beta-adrenergic stimulation via cAMP-dependent protein kinase

To investigate possible effects of adrenergic stimulation on G protein-activated inwardly rectifying K(+) channels (GIRK), acetylcholine (ACh)-evoked K(+) current, I(KACh), was recorded from adult rat atrial cardiomyocytes using the whole cell patch clamp method and a fast perfusion system. The rise...

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Veröffentlicht in:	The Journal of general physiology 2000-05, Vol.115 (5), p.547-558
Hauptverfasser:	Müllner, C, Vorobiov, D, Bera, A K, Uezono, Y, Yakubovich, D, Frohnwieser-Steinecker, B, Dascal, N, Schreibmayer, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adrenergic beta-Agonists - pharmacology Anatomy & physiology Animals Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Inhibitors - pharmacology G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression - physiology Heart Atria - chemistry Heart Atria - cytology Heart Atria - enzymology Ion Channel Gating - drug effects Ion Channel Gating - physiology Isoproterenol - pharmacology Isoquinolines - pharmacology Membrane Potentials - drug effects Membrane Potentials - physiology Muscle Fibers, Skeletal - chemistry Muscle Fibers, Skeletal - enzymology Myocardium - chemistry Myocardium - cytology Myocardium - enzymology Oocytes - physiology Original Phosphorylation Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Proteins Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta - physiology Rodents Sulfonamides Thionucleotides - pharmacology Vasodilator Agents - pharmacology Xenopus laevis
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