Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol

In steady state, the Ca content of the sarcoplasmic reticulum (SR) of cardiac myocytes is determined by a balance among influx and efflux pathways. The SR Ca content may be limited mainly by the ATP-supplied chemical potential that is inherent in the gradient between SR and cytosol. That is, forward...

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Veröffentlicht in:	The Journal of general physiology 1998-04, Vol.111 (4), p.491-504
Hauptverfasser:	Ginsburg, K S, Weber, C R, Bers, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Calcium - metabolism Calcium-Transporting ATPases - drug effects Calcium-Transporting ATPases - metabolism Cardiotonic Agents - pharmacology Cells Cellular biology Ferrets Heart Heart Ventricles Homeostasis - physiology Isoproterenol - pharmacology Myocardium - cytology Myocardium - metabolism Pharmacology Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Thapsigargin - pharmacology
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