Functional consequences of lidocaine binding to slow-inactivated sodium channels

Na channels open upon depolarization but then enter inactivated states from which they cannot readily reopen. After brief depolarizations, native channels enter a fast-inactivated state from which recovery at hyperpolarized potentials is rapid (< 20 ms). Prolonged depolarization induces a slow-in...

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Veröffentlicht in:	The Journal of general physiology 1996-05, Vol.107 (5), p.643-658
Hauptverfasser:	Balser, J R, Nuss, H B, Romashko, D N, Marban, E, Tomaselli, G F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthetics, Local - metabolism Anesthetics, Local - pharmacology Animals Brain - cytology Brain - drug effects Brain Chemistry - drug effects Brain Chemistry - physiology Cellular biology Female Ion Channel Gating - drug effects Ion Channel Gating - physiology Kinetics Lidocaine - metabolism Lidocaine - pharmacology Medical research Membrane Potentials - drug effects Membrane Potentials - physiology Models, Biological Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Oocytes - metabolism Patch-Clamp Techniques Rats Sodium Channels - drug effects Sodium Channels - metabolism Studies Xenopus laevis
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