A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins

GTP-binding (G) proteins have been shown to mediate activation of inwardly rectifying potassium (K+) channels in cardiac, neuronal and neuroendocrine cells. Here, we report functional expression of a recombinant inwardly rectifying channel which we call KGP (or hpKir3.4), to signify that it is K+ se...

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Veröffentlicht in:	The Journal of general physiology 1996-03, Vol.107 (3), p.381-397
Hauptverfasser:	Chan, K W, Langan, M N, Sui, J L, Kozak, J A, Pabon, A, Ladias, J A, Logothetis, D E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - physiology Amino Acid Sequence Anatomy & physiology Animals Base Sequence Blotting, Northern Cellular biology CHO Cells Cricetinae DNA Probes Electrophysiology GTP-Binding Proteins - biosynthesis GTP-Binding Proteins - metabolism Guinea Pigs Humans Immunoblotting Ion Channel Gating - physiology Molecular Sequence Data Oocytes - metabolism Pancreas Pertussis Toxin Polymerase Chain Reaction Potassium Potassium Channels - biosynthesis Potassium Channels - metabolism Precipitin Tests Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Transcription, Genetic Virulence Factors, Bordetella - pharmacology Xenopus laevis
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