Autoimmune Th2-Mediated Dacryoadenitis in MRL/MpJ Mice Becomes Th1-Mediated in IL-4 Deficient MRL/MpJ Mice

MRL/MpJ mice of substrains MRL/MpJ-fas(+)/fas(+) (MRL/+) and MRL/MpJ-fas(lpr)/fas(lpr) (MRL/lpr) spontaneously develop autoimmune dacryoadenitis and sialadenitis and are a model for the human disorder Sjögren syndrome. The dacryoadenitis in both substrains appears to be Th2 in nature, with little IF...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2007-12, Vol.48 (12), p.5624-5629
Hauptverfasser:	Jabs, Douglas A, Prendergast, Robert A, Campbell, Adam L, Lee, Bella, Akpek, Esen Karamursel, Gerard, Herve C, Hudson, Alan P, Whittum-Hudson, Judith A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - immunology Autoimmune Diseases - pathology B7-1 Antigen - metabolism B7-2 Antigen - metabolism Biological and medical sciences Dacryocystitis - immunology Dacryocystitis - pathology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Gene Silencing - physiology Immunoenzyme Techniques Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-13 - genetics Interleukin-13 - metabolism Interleukin-4 - genetics Male Mice Mice, Inbred BALB C Mice, Inbred MRL lpr Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Th1 Cells - immunology Th2 Cells - immunology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!