Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released

Platelets, in addition to their function in hemostasis, play an important role in wound healing and tumor growth. Because platelets contain angiogenesis stimulators and inhibitors, the mechanisms by which platelets regulate angiogenesis remain unclear. As platelets adhere to activated endothelium, t...

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Veröffentlicht in:	Blood 2008-02, Vol.111 (3), p.1227-1233
Hauptverfasser:	Italiano, Joseph E., Richardson, Jennifer L., Patel-Hett, Sunita, Battinelli, Elisabeth, Zaslavsky, Alexander, Short, Sarah, Ryeom, Sandra, Folkman, Judah, Klement, Giannoula L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - metabolism Blood Platelets - ultrastructure Hemostasis, Thrombosis, and Vascular Biology Humans Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Microscopy, Immunoelectron Neovascularization, Physiologic Peptide Hydrolases - metabolism
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