Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity

Asymmetrical localization of transcripts coupled with localized translation constitutes an important mechanism widely deployed to regulate gene activity in a spatial manner. The conserved transmembrane protein Crumbs (Crb) is an important regulator of epithelial polarity. However, it remains unclear...

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Veröffentlicht in:	The Journal of cell biology 2008-01, Vol.180 (1), p.31-38
Hauptverfasser:	Li, Zhouhua, Wang, Liwei, Hays, Thomas S, Cai, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biochemistry Cell membranes Cell Polarity Cells Cellular biology Drosophila Drosophila melanogaster Drosophila melanogaster - cytology Drosophila melanogaster - embryology Drosophila melanogaster - metabolism Drosophila Proteins - analysis Drosophila Proteins - genetics Drosophila Proteins - metabolism Dyneins - genetics Dyneins - physiology Embryo, Nonmammalian - metabolism Embryos Epithelial cells Epithelial Cells - chemistry Epithelial Cells - cytology Epithelial Cells - metabolism Gene expression regulation Guanylate Kinases Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins - metabolism Messenger RNA Mutation Nucleoside-Phosphate Kinase - metabolism Protein Sorting Signals Protein Transport Proteins Ribonucleic acid RNA RNA, Messenger - analysis RNA, Messenger - metabolism Transgenes Untranslated regions
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