Eya4-deficient mice are a model for heritable otitis media

Otitis media is an extremely common pediatric inflammation of the middle ear that often causes pain and diminishes hearing. Vulnerability to otitis media is due to eustachian tube dysfunction as well as other poorly understood factors, including genetic susceptibility. As EYA4 mutations cause sensor...

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Veröffentlicht in:	The Journal of clinical investigation 2008-02, Vol.118 (2), p.651-658
Hauptverfasser:	Depreux, Frederic F S, Darrow, Keith, Conner, David A, Eavey, Roland D, Liberman, M Charles, Seidman, Christine E, Seidman, J G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Complications and side effects Disease Models, Animal Ear diseases Ear, Middle - abnormalities Eardrum Ears & hearing Eustachian Tube - abnormalities Gene mutations Genes Genetic aspects Genetic Predisposition to Disease Hearing loss Hearing Loss, Sensorineural - genetics Hearing protection Inflammation Mice Mice, Mutant Strains Mutation Otitis media Otitis Media with Effusion - genetics Pediatrics Phosphatase Risk factors Stem cells Trans-Activators - genetics
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