GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells

GATA-2 is an essential transcription factor in the hematopoietic system that is expressed in hematopoietic stem cells (HSCs) and progenitors. Complete deficiency of GATA-2 in the mouse leads to severe anemia and embryonic lethality. The role of GATA-2 and dosage effects of this transcription factor...

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Veröffentlicht in:	The Journal of experimental medicine 2004-10, Vol.200 (7), p.871-882
Hauptverfasser:	Ling, Kam-Wing, Ottersbach, Katrin, van Hamburg, Jan Piet, Oziemlak, Aneta, Tsai, Fong-Ying, Orkin, Stuart H, Ploemacher, Rob, Hendriks, Rudi W, Dzierzak, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - physiology Bone Marrow - physiology Cesium Radioisotopes DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Female Flow Cytometry GATA2 Transcription Factor Gene Dosage Gonads - physiology Hematopoietic Stem Cells - physiology Immunohistochemistry Mesonephros - physiology Mice Mice, Inbred C57BL Microscopy, Confocal Polymerase Chain Reaction - methods Spleen - anatomy & histology Time Factors Transcription Factors - genetics Transcription Factors - physiology
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