CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells

Antigen immunodominance is an unexplained feature of CD8+ T cell responses to herpesviruses, which are agents whose lytic replication involves the sequential expression of immediate early (IE), early (E), and late (L) proteins. Here, we analyze the primary CD8 response to Epstein-Barr virus (EBV) in...

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Veröffentlicht in:	The Journal of experimental medicine 2005-02, Vol.201 (3), p.349-360
Hauptverfasser:	Pudney, Victoria A, Leese, Alison M, Rickinson, Alan B, Hislop, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Affinity Antigen Presentation CD8-Positive T-Lymphocytes - immunology Epstein-Barr Virus Infections - immunology Epstein-Barr Virus Nuclear Antigens - immunology HLA Antigens - immunology Humans Immunodominant Epitopes Virus Replication
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