Tuberculosis in children and adults: two distinct genetic diseases

Disseminated disease in children and pulmonary disease in adults constitute two major epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of infected individuals develop clinical tuberculosis, typically one form of the disease or the other. Mendelian and complex...

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Veröffentlicht in:	The Journal of experimental medicine 2005-12, Vol.202 (12), p.1617-1621
Hauptverfasser:	Alcaïs, Alexandre, Fieschi, Claire, Abel, Laurent, Casanova, Jean-Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bayes Theorem Chemokine CCL2 - genetics Child Genetic Predisposition to Disease Humans Inheritance Patterns - immunology Mycobacterium Mycobacterium - immunology Receptors, Interleukin - metabolism Receptors, Interleukin-12 Tuberculosis - epidemiology Tuberculosis - genetics Tuberculosis - immunology
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