Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

TANK-binding kinase-1 (TBK1) and the inducible IkappaB kinase (IKK-i) have been shown recently to activate interferon (IFN) regulatory factor-3 (IRF3), the primary transcription factor regulating induction of type I IFNs. Here, we have compared the role and specificity of TBK1 in the type I IFN resp...

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Veröffentlicht in:	The Journal of experimental medicine 2004-06, Vol.199 (12), p.1651-1658
Hauptverfasser:	Perry, Andrea K, Chow, Edward K, Goodnough, Julia B, Yeh, Wen-Chen, Cheng, Genhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology Antigens, CD - physiology DNA-Binding Proteins - physiology Interferon Regulatory Factor-3 Interferon Type I - immunology Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Membrane Glycoproteins - immunology Mice Mice, Knockout Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Cell Surface - immunology Receptors, Tumor Necrosis Factor - deficiency Receptors, Tumor Necrosis Factor - immunology Receptors, Tumor Necrosis Factor - physiology Receptors, Tumor Necrosis Factor, Type I RNA, Double-Stranded - genetics Sendai virus Toll-Like Receptors Transcription Factors - physiology Virus Diseases - immunology
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